Emerging role of microRNAs as regulators of protein kinase C substrate MARCKS and MARCKSL1 in cancer

Yadav, Vikas; Jena, Manoj Kumar; Parashar, Gaurav; Parashar, Nidarshana Chaturvedi; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh

doi:10.1016/j.yexcr.2023.113891

Experimental Cell Research

2024

DOI: 10.1016/j.yexcr.2023.113891

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Emerging role of microRNAs as regulators of protein kinase C substrate MARCKS and MARCKSL1 in cancer

Vikas Yadav,

Manoj Kumar Jena,

Gaurav Parashar

et al.

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2024

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Cited by 1 publication

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Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

Yadav,

Singh,

Sharma

et al. 2024

Cancers

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Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R (HuR) is a prominent RBP known to drive tumorigenesis with a pivotal role in CRC. In this review, we discuss the regulatory role of the HuR/miRNA axis in CRC. Interestingly, miRNAs can directly target HuR, altering its expression and activity. However, HuR can also stabilize or degrade miRNAs, forming complex feedback loops that either activate or block CRC-associated signaling pathways. Dysregulation of the HuR/miRNA axis contributes to CRC initiation and progression. Additionally, HuR-miRNA regulation by other small non-coding RNAs, circular RNA (circRNAs), or long-non-coding RNAs (lncRNAs) is also explored here. Understanding this HuR-miRNA interplay could reveal novel biomarkers with better diagnostic or prognostic accuracy.

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Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

Yadav,

Singh,

Sharma

et al. 2024

Cancers

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Emerging role of microRNAs as regulators of protein kinase C substrate MARCKS and MARCKSL1 in cancer

Cited by 1 publication

References 118 publications

Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

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