Emerging role of microRNAs and long non-coding RNAs in COVID-19 with implications to therapeutics

Arman, Kaifee; Dalloul, Zeinab; Bozgeyik, Esra

doi:10.1016/j.gene.2023.147232

Cited by 10 publications

(4 citation statements)

References 219 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SARS-CoV-2 infection is associated with the so-called "cytokine storm" [22]. We observed upregulation of the pro-inflammatory cytokine IL-6, IFNγ, and TNF-α genes and downregulation of the cxcl2 gene (a potent neutrophil chemoattractant) in the tuberculoma wall of TB patients compared with gene expression in distant parenchymal tissues of the same patients.…”

Section: Discussionmentioning

confidence: 77%

Lung Inflammation Signature in Post-COVID-19 TB Patients

Shepelkova,

Evstifeev,

Berezovskiy

et al. 2023

IJMS

View full text Add to dashboard Cite

Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, despite the COVID-19 pandemic. The mechanisms by which SARS-CoV-2 affects tuberculosis progression have not yet been established. Here, we compared the level of inflammation in the wall of the tuberculoma and in the parenchymal lung tissue of 30 patients diagnosed with tuberculoma without a history of COVID-19 and 30 patients diagnosed with tuberculoma 3 months after COVID-19. We also characterized TB activity in these patients using a panel of TB-associated miRNAs. Histopathological changes were examined in the resection material, and the expression level of cytokine/chemokine genes was determined by qRT-PCR. In patients with a history of COVID-19, the histological data obtained suggested activation of tuberculosis. In the same group of patients, as opposed to those without a history of COVID-19, equally high levels of pro-inflammatory cytokines/chemokines were expressed both in the tuberculoma wall and in the periphery of the resected specimen. A full set of miRNAs (miR-191, miR-193a, miR-222, miR-223, miR-155, miR-26a, and miR-150) were downregulated in the sera of patients with TB and active COVID-19 co-infection compared to controls. Our observations indicate signs of tuberculosis activation resulting from COVID-19 infection.

show abstract

Section: Discussionmentioning

confidence: 77%

Lung Inflammation Signature in Post-COVID-19 TB Patients

Shepelkova,

Evstifeev,

Berezovskiy

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Interestingly, from this list miR‐15a‐5p and miR‐31‐5p appeared in two or more studies 56,57,73,78,82,84,86 and could potentially serve as biomarkers for disease severity. Table 3 summarises the targets and principle cellular pathways associated with miRNAs regulated during Inf vs C and S vs C stages and cited previously 46,56,73,88–120 . Most of the miRNAs were involved in targeting virus‐host interactions, viral replication, and host‐immune responses.…”

Section: Resultsmentioning

confidence: 97%

Differentially‐regulated miRNAs in COVID‐19: A systematic review

Ahmad

Gull

Baby

et al. 2023

Reviews in Medical Virology

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease of 2019 that infected more than 760 million people worldwide with over 6.8 million deaths to date. COVID-19 is one of the most challenging diseases of our times due to the nature of its spread, its effect on multiple organs, and an inability to predict disease prognosis, ranging from being completely asymptomatic to death. Upon infection, SARS-CoV-2 alters the host immune response by changing host-transcriptional machinery. MicroRNAs (miRNAs) are regarded as post-transcriptional regulators of gene expression that can be perturbed by invading viruses. Several in vitro and in vivo studies have reported such dysregulation of host miRNA expression upon SARS-CoV-2 infection. Some of this could occur as an anti-viral response of the host to the viral infection. Viruses themselves can counteract that response by mounting their own pro-viral response that facilitates virus infection, an aspect which may cause pathogenesis. Thus, miRNAs could serve as possible disease biomarkers in infected people. In the current review, we have summarised and analysed the existing data about miRNA dysregulation in patients infected with SARS-CoV-2 to determine their concordance between studies, and identified those that could serve as potential biomarkers during infection, disease progression, and death, even in people with other comorbidities. Having such biomarkers can be vital in not only predicting prognosis, but also the development of novel miRNA-based anti-virals and Abbreviations: 3 0 UTR, 3 0 untranslated regions; 5 0 UTR, 5 0

show abstract

“…In other infections caused by Japanese encephalitis virus (JEV), Rabies Lyssavirus (RV), Herpes Simplex virus (HSV), and Influenza A virus (IAV), NEAT1 has been found to significantly increase, which, as a result, represses the transcription of interleukin IL-8 signaling [48]. Remarkably, the human cellular barriers that SAR-CoV2 crossed also affected the expression of lncRNAs [49][50][51]. Both NEAT1 and MALAT1 were also found to be differentially expressed in patients with severe COVID-19 [52].…”

Section: Category: Examples Of Human-ncrnas Associated With the Immun...mentioning

confidence: 99%

Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Bermudez-Santana,

Gallego-Gómez

2024

Viruses

View full text Add to dashboard Cite

In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules of cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs and their interplay are strongly disturbed during viral infections. Nevertheless, the folding of RNA virus genomes has also been identified as a critical factor in regulating canonical and non-canonical functions. Due to the influence of host ncRNAs and the structure of RNA viral genomes, complex molecular and cellular processes in infections are modulated. We propose three main categories to organize the current information about RNA–RNA interactions in some well-known human viruses. The first category shows examples of host ncRNAs associated with the immune response triggered in viral infections. Even though miRNAs introduce a standpoint, they are briefly presented to keep researchers moving forward in uncovering other RNAs. The second category outlines interactions between virus-host ncRNAs, while the third describes how the structure of the RNA viral genome serves as a scaffold for processing virus-derived RNAs. Our grouping may provide a comprehensive framework to classify ncRNA–host-cell interactions for emerging viruses and diseases. In this sense, we introduced them to organize DENV–host-cell interactions.

show abstract

Emerging role of microRNAs and long non-coding RNAs in COVID-19 with implications to therapeutics

Cited by 10 publications

References 219 publications

Lung Inflammation Signature in Post-COVID-19 TB Patients

Lung Inflammation Signature in Post-COVID-19 TB Patients

Differentially‐regulated miRNAs in COVID‐19: A systematic review

Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Contact Info

Product

Resources

About