Emerging role of lncRNAs in osteoarthritis: An updated review

Abstract

Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The molecular mechanism underlying OA pathogenesis is multifactorial. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with length more than 200 nucleotides. They have various functions such as modulating transcription and protein activity, as well as forming endogenous small interfering RNAs (siRNAs) and microRNA (miRNA) sponges. Emerging evidence suggests that lncRNAs might be involved in the pathogenesis of OA which opens up a new avenue for the development of new biomarkers and therapeutic strategies. The purpose of this review is to summarize the current clinical and basic experiments related to lncRNAs and OA with a focus on the extensively studied H19, GAS5, MALAT1, XIST and HOTAIR. The potential translational value of these lncRNAs as therapeutic targets for OA is also discussed.

ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression

“… 27 Recently, accumulating evidence indicated that lncRNA dysregulation plays important roles in OA progression by cartilage degradation, synovial inflammation, and dysfunction of subchondral bone homeostasis and that lncRNAs could serve as therapeutic targets. 28 , 29 , 30 Therefore, an expanded understanding of the functions and regulatory mechanisms of lncRNAs in OA may provide potential therapeutic targets for OA.…”

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

“…It has been reported that lncRNA H19 is an important lncRNA in the pathogenesis of OA. One of these studies showed that knockdown of lncRNA H19 alleviated apoptosis and inflammation by sponging miR130a in LPS-stimulated human C28/I2 chondrocytes ( 99 , 100 ), and studying the combination of these drugs with nonsteroidal anti-inflammatory drugs is highly important for targeted treatment.…”

“…GAS5, which is involved in GR activity, is a lncRNA of great interest to researchers in recent years ( 102 ). GAS5 is an important lncRNA in OA patients ( 99 ). GAS5 is downregulated in OA patients mainly in articular cartilage tissues and synovial cells.…”

“…Upregulation of lncRNAs appears to be the most common abnormal change reported in the pathogenesis of OA ( 99 ). It is reasonable to propose methods to inhibit the expression or activity of these genes.…”

The emerging role of lncRNAs in osteoarthritis development and potential therapy

“…LncRNAs with longer than 200 nucleotides have been identified to involve in diverse diseases via regulating gene expression and chromatin remodeling, including cancer, neurodegenerative diseases and cardiovascular disorders ( Jiang et al, 2020 ; Cheng et al, 2022 ; Gareev et al, 2022 ; Sufianova et al, 2022 ; Xie et al, 2022 ). LncRNAs have gained significant attention and play crucial regulatory roles in osteoarthritis ( Chen et al, 2017 ; Abbasifard et al, 2020 ; Tu et al, 2020 ; Wang et al, 2022 ; Okuyan and Begen, 2022 ). In this review, we will describe the role of numerous lncRNAs in osteoarthritis development and progression.…”