Emerging role of integrated PET-MRI in osteoarthritis

Jena, Amarnath; Taneja, Sangeeta; Rana, Prerana; Goyal, Nidhi; Vaish, Abhishek; Botchu, Rajesh; Vaishya, Raju

doi:10.1007/s00256-021-03847-z

Cited by 23 publications

(14 citation statements)

References 108 publications

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“…It has shown high uptake values in patients without radiographic evidence of joint space narrowing and correlates well with pain in patients with early or progressive OA [ 35 ]. Thus, fusing PET images with the unparalleled soft-tissue contrast of MRI to provide molecular-level data holds great promise to understand the complex disease process affecting articular cartilage [ 36 ] ( Figure 7 ).…”

Section: Cartilage Imagingmentioning

confidence: 99%

Imaging of Cartilage and Chondral Defects: An Overview

Nischal

Iyengar

Herlekar

et al. 2023

Life

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A healthy articular cartilage is paramount to joint function. Cartilage defects, whether acute or chronic, are a significant source of morbidity. This review summarizes various imaging modalities used for cartilage assessment. While radiographs are insensitive, they are still widely used to indirectly assess cartilage. Ultrasound has shown promise in the detection of cartilage defects, but its efficacy is limited in many joints due to inadequate visualization. CT arthrography has the potential to assess internal derangements of joints along with cartilage, especially in patients with contraindications to MRI. MRI remains the favored imaging modality to assess cartilage. The conventional imaging techniques are able to assess cartilage abnormalities when cartilage is already damaged. The newer imaging techniques are thus targeted at detecting biochemical and structural changes in cartilage before an actual visible irreversible loss. These include, but are not limited to, T2 and T2* mapping, dGEMRI, T1 imaging, gagCEST imaging, sodium MRI and integrated PET with MRI. A brief discussion of the advances in the surgical management of cartilage defects and post-operative imaging assessment is also included.

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Section: Cartilage Imagingmentioning

confidence: 99%

Imaging of Cartilage and Chondral Defects: An Overview

Nischal

Iyengar

Herlekar

et al. 2023

Life

Self Cite

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“…25 Similarly, in knees with osteoarthritis or in knees after biomechanical loading, subtle BME-like changes on MRI were associated with increased tracer uptake at NaF PET/MRI. [26][27][28] Direct demonstration of the association between BMElike signal in osteoarthritis and accelerated bone remodeling was obtained by Shabestari et al based on histomorphometric studies from human bone specimens with and without BME-like signal at preoperative MRI. 29 Bone specimens with BME-like signal demonstrated a 22-fold increase in bone turnover (expressed as bone formation rate per unit of bone surface) and a 13-fold increase in the mineralizing surface compared with bones without BME-like signal.…”

Section: Accelerated Bone Remodelingmentioning

confidence: 99%

Magnetic Resonance Imaging of Accelerated Bone Remodeling

Berg

Mourad

Omoumi

2023

Semin Musculoskelet Radiol

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A regional acceleration of bone remodeling may possibly follow biomechanical insults to the bone. This review assesses the literature and clinical arguments supporting the hypothetical association between accelerated bone remodeling and bone marrow edema (BME)-like signal intensity on magnetic resonance imaging. BME-like signal is defined as a confluent ill-delimited area of bone marrow with a moderate decrease in signal intensity on fat-sensitive sequences and a high signal intensity on fat-suppressed fluid-sensitive sequences. In addition to this confluent pattern, a linear subcortical pattern and a patchy disseminated pattern have also been recognized on fat-suppressed fluid-sensitive sequences. These particular BME-like patterns may remain occult on T1-weighted spin-echo images. We hypothesize that these BME-like patterns, with particular characteristics in terms of distribution and signal, are associated with accelerated bone remodeling. Limitations in recognizing these BME-like patterns are also discussed.

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“…Furthermore, hybrid PET-MRI systems, which have been around now for 10 years, not only offer to add these important functional imaging markers to benchmark MRI morphologic and microstructural soft-tissue markers, but also to study how these different features interact in disease onset and progression. 39 , 40 …”

Section: Pet-mri In Oa Imagingmentioning

confidence: 99%

Latest advancements in imaging techniques in OA

Hayashi

Roemer

Link

et al. 2022

Therapeutic Advances in Musculoskeletal

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The osteoarthritis (OA) research community has been advocating a shift from radiography-based screening criteria and outcome measures in OA clinical trials to a magnetic resonance imaging (MRI)-based definition of eligibility and endpoint. For conventional morphological MRI, various semiquantitative evaluation tools are available. We have lately witnessed a remarkable technological advance in MRI techniques, including compositional/physiologic imaging and automated quantitative analyses of articular and periarticular structures. More recently, additional technologies were introduced, including positron emission tomography (PET)-MRI, weight-bearing computed tomography (CT), photon-counting spectral CT, shear wave elastography, contrast-enhanced ultrasound, multiscale X-ray phase contrast imaging, and spectroscopic photoacoustic imaging of cartilage. On top of these, we now live in an era in which artificial intelligence is increasingly utilized in medicine. Osteoarthritis imaging is no exception. Successful implementation of artificial intelligence (AI) will hopefully improve the workflow of radiologists, as well as the level of precision and reproducibility in the interpretation of images.

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Emerging role of integrated PET-MRI in osteoarthritis

Cited by 23 publications

References 108 publications

Imaging of Cartilage and Chondral Defects: An Overview

Imaging of Cartilage and Chondral Defects: An Overview

Magnetic Resonance Imaging of Accelerated Bone Remodeling

Latest advancements in imaging techniques in OA

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