Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

Martin, Jérôme C.; Baeten, Dominique; Josien, Régis

doi:10.1016/j.clim.2014.05.004

Cited by 115 publications

(97 citation statements)

References 141 publications

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“…There is experimental evidence regarding the involvement of IL-17 in lupus-like inflammation from studies in knockout mouse, where IL-17A can contribute toward the development of renal immune deposits (25). The evidence for a role in the pathophysiology of human SLE is less striking (11). A number of studies, mainly from Asian cohorts, showed a correlation of IL-17A levels or the number of Th17 cells with disease activity or organ damage (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

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IL-17A levels in systemic lupus erythematosus associated with inflammatory markers and lower rates of malignancy and heart damage: Evidence for a dual role

Raymond¹,

Ostli-Eilertsen²,

Griffiths³

et al. 2017

Eur J Rheumatol

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Objective: The interleukin 17 (IL-17) cytokine family is involved in a number of chronic inflammatory diseases. In spite of contradictory findings and a lack of causality in clinical studies, IL-17 inhibition for systemic lupus erythematosus (SLE) has regained attention as a potential therapeutic pathway, after demonstrating disease-modifying capabilities in ankylosing spondylitis. We investigated the clinical associations of interleukin 17 A (IL-17A) in patients with SLE.Material and Methods: A cross-sectional study was performed involving SLE patients (n=102; age: 49 years; 86% female) recruited from a regional registry. IL-17A levels were determined by immunoassay, disease activity by Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K), and cumulative damage by Systemic Lupus International Collaborative Clinics Damage Index (SDI) scores. Non-parametric techniques were used to examine the association between IL-17A and disease activity and autoantibody profiles were compared with healthy controls (n=31): principal component analysis (PCA) was used to determine the interplay of immune cells across disease states and damage development in SLE patients.Results: SLE patients had higher IgG levels, lower T-cell and B-cell counts, but median IL-17A levels did not differ from the controls (28.4 vs. 28.4 pg/mL, p=0.9). In SLE patients, IL-17A did not correlate with SLEDAI-2K or SDI, but was inversely related with age (correlation coefficients, Rs.=-0.29, p<0.05), systolic blood pressure (Rs.=-0.31, p<0.05), years of smoking (Rs.=-0.43, p<0.05), cumulative heart (Rs.=-0.22, p<0.05), and malignancy damage (Rs.=-0.18, p<0.05). Serological correlations for IL-17A existed with immunoglobulin G (IgG) levels (Rs.=0.21, p<0.05), high sensitivity C-reactive protein (hs-CRP) levels (Rs.=0.28, p<0.05), proteinuria (Rs.=0.64, p<0.05), and pre-albumin (Rs.=-0.22, p<0.05). Longitudinal data showed only modest fluctuation in IL-17A levels, independent of SLEDAI-2K. Conclusion:These results suggest that IL-17A, while participating in inflammation, may also serve a protective purpose in SLE patients.

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Section: Discussionmentioning

confidence: 99%

“…Increased IL-17A levels have also been reported in the sera of SLE patient subsets, particularly those with LN (4)(5)(6). Furthermore, in lupus-prone mice, the over-expression of IL-17A and subsequent expansion of DN T cells in the tubulointerstitial space has been linked to the development of nephritis (4,(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 91%

IL-17A levels in systemic lupus erythematosus associated with inflammatory markers and lower rates of malignancy and heart damage: Evidence for a dual role

Raymond¹,

Ostli-Eilertsen²,

Griffiths³

et al. 2017

Eur J Rheumatol

View full text Add to dashboard Cite

show abstract

“…A strong association of IL-17A and other T H 17 cytokines in SLE pathogenesis in mouse model has been reported (20,72). IL-23 cytokine, which is elevated in SLE patient sera, contributes to the terminal differentiation of pathogenic T H 17 cells.…”

Section: Fc␥riiia (Cd16a) Co-localizes With Tlrs In Cd4mentioning

confidence: 99%

“…T H 17 responses are observed both in inflammation and in autoimmunity (20,28). IL-17 cytokines are necessary for the development of severe glomerulonephritis (29).…”

Section: Ics In Cd4mentioning

confidence: 99%