Emerging role of Centella asiatica in improving age-related neurological antioxidant status

Subathra, Marimuthu; Samuel, Shila; Devi, Muthuswamy Anusuya; Panneerselvam, Chinnakkannu

doi:10.1016/j.exger.2005.06.001

Cited by 97 publications

(54 citation statements)

References 45 publications

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“…We observed a significant increase in LPO production in the brains of aged animals consistent with the recent report by Subathra et al (2005). Lipid peroxidation is a complex process, and polyunsaturated fatty acids are readily susceptible to autoxidation.…”

Section: Lipid Peroxidation In Aged Rat Brainsupporting

confidence: 79%

Age-related changes in glutathione and glutathione-related enzymes in rat brain

2006

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The most reliable and robust risk factor for some neurodegenerative diseases is aging. It has been proposed that processes of aging are associated with the generation of reactive oxygen species and a disturbance of glutathione homeostasis in the brain. Yet, aged animals have rarely been used to model the diseases that are considered to be age-related such as Parkinson's or Alzheimer's disease. This suggests that the results from these studies would be more valuable if aged animals were used. The present study was designed to provide insight into the glutathione redox state in young and aged rat siblings of both genders by studying the enzyme activities related to glutathione synthesis, cycling, and usage. The results suggested a significant age-related reduction of reduced glutathione (GSH) level in all brain regions examined, associated with an increase of GSH oxidation to glutathione disulfide (GSSG) and decrease of the GSH/GSSG ratio. These changes were accompanied by diminished γ-glutamylcysteine synthetase activity in de novo glutathione synthesis and increased lipid peroxidation. In addition, these changes were associated with increased enzyme activities related to the GSH usage (glutathione peroxidase, γ-glutamyl transpeptidase, and glutathione Stransferase). The results indicate that aged animals are likely more vulnerable to oxidative stress and insinuate the roles of aged animals in modeling age-related neurodegeneration diseases.

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Section: Lipid Peroxidation In Aged Rat Brainsupporting

confidence: 79%

Age-related changes in glutathione and glutathione-related enzymes in rat brain

2006

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“…Centella asiatica has been shown in vivo to prevent the cognitive deficits that occur following treatment with streptozotocin and to protect cholinergic neurons from the toxic effects of aluminium . In addition, Centella asiatica treatment decreased protein carbonyl production in the brains of aged rats (Subathra et al, 2005). These data suggest that Centella asiatica may reduce Alzheimer's disease neuropathology.…”

Section: Introductionmentioning

confidence: 54%

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Dhanasekaran

Holcomb

Hitt

et al. 2008

Phytotherapy Research

165

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PSAPP mice expressing the 'Swedish' amyloid precursor protein and the M146L presenilin 1 mutations are a well-characterized model for spontaneous amyloid β β β β β plaque formation. Centella asiatica has a long history of use in India as a memory enhancing drug in Ayurvedic literature. The study investigated whether Centella asiatica extract (CaE) can alter the amyloid pathology in PSAPP mice by administering CaE (2.5 or 5.0 g/kg/day) starting at 2 months of age prior to the onset of detectable amyloid deposition and continued for either 2 months or 8 months. A significant decrease in amyloid β β β β β 1-40 and 1-42 was detectable by ELISA following an 8 month treatment with 2.5 mg/kg of CaE. A reduction in Congo Red stained fibrillar amyloid plaques was detected with the 5.0 mg/kg CaE dose and long-term treatment regimen. It was also confirmed that CaE functions as an antioxidant in vitro, scavenging free radicals, reducing lipid peroxidation and protecting against DNA damage. The data indicate that CaE can impact the amyloid cascade altering amyloid β β β β β pathology in the brains of PSAPP mice and modulating components of the oxidative stress response that has been implicated in the neurodegenerative changes that occur with Alzheimer's disease.

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“…[43]. The herb is well known for its high medicinal values; its antioxidant activity [44] and non-toxicity motivated us to carry out the present investigation.…”

Section: Introductionmentioning

confidence: 99%

Photobiological synthesis of noble metal nanoparticles using Hydrocotyle asiatica and application as catalyst for the photodegradation of cationic dyes

2015

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Solar light induced photo catalysis by plasmonic nanoparticles such as Au and Ag is an important field in green chemistry. In this study an environmental benign method was investigated for the rapid synthesis of colloidal Ag and AuNPs using the extract of Hydrocotyle asiatica, as a reducing and stabilizing agent under sunlight irradiation. The nanoparticles were formed in few seconds and were characterized by UV-Vis., FT-IR, TEM, EDAX, XRD, DLS and Zetasizer. The nanoparticles were stable in aqueous solution for more than 6 months. TEM analysis established that the Ag and AuNPs were predominantly spherical with average size of 21 and 8 nm, respectively. The flavonoids and glycosides from the extract of H. asiatica were proved to be responsible for the reduction and capping through FT-IR analysis. The antimicrobial studies of AgNPs showed effective inhibitory activity against the clinical strains of gram-negative and positive bacteria. The localized surface plasmon resonance of AgNPs was used for the photo-driven degradation of cationic dyes (malachite green and methylene blue). Thus, this green technique can be used for bulk production of AgNPs, and thus prepared nanoparticles may be used for removal of dyes from effluent. Graphical Abstract

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Emerging role of Centella asiatica in improving age-related neurological antioxidant status

Cited by 97 publications

References 45 publications

Age-related changes in glutathione and glutathione-related enzymes in rat brain

Age-related changes in glutathione and glutathione-related enzymes in rat brain

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Photobiological synthesis of noble metal nanoparticles using Hydrocotyle asiatica and application as catalyst for the photodegradation of cationic dyes

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