Emerging role for PLCβ1 MiRNA and disease

Abstract

Nuclear inositides are independently regulated and their regulation is completely independent from the plasma membrane correspondent, hinting that the nucleus represents a specialized distinct compartment of inositol lipids metabolism. This points out that nuclear inositol lipids themselves can influence nuclear key events as transcription and pre-mRNA splicing, growth, proliferation, cell cycle regulation and differentiation. Phospholipase C β1 (PLCβ1) is the most significant enzyme for nuclear inositide signaling. Very recently it has been highlighted that the role of PLCβ1 during erythropoiesis is linked to that of miR-210. Moreover, PLCβ1 signaling is linked to gene regulation and changes in microRNAs (miRNAs) occur with PLCβ1 expression. Molecular targets of PLCβ1 have been found to be important during myogenesis and hematopoiesis. In addition, PLCβ1 signaling has been demonstrated to be impaired in diseases affecting both myogenic differentiation and affecting the hematopoietic system.