Emerging Role for Pharmacogenomics in HIV Research in Africa

Abstract

Tweetable abstract Pharmacogenomics (Pgx); the study of how genes affect drug response may optimize treatment by improving effectiveness and safety of medications. To apply current guidelines for African HIV-infected patients Pgx research is key.

Editorial: Is there still room for pharmacogenetics in 2023? The cases of infectious diseases and oncology

“…Particularly, the article by Ragia et al emphasizes the significance of implementing DPYD genotyping in Greek cancer patients receiving fluoropyrimidine-based chemotherapy. This article underlines the role of genetic variants in different populations, not considering only a global population (e.g., Caucasian): some genetic polymorphisms could have not an impact in some ethnicities, as reported for example, for abacavir and HLA-B*5701 in Sub-Saharan African population ( Zhou et al, 2021 ). This genetic polymorphism predicts which patients treated with abacavir are more likely to develop hypersensitivity reaction, which could be severe and potentially fatal ( Dean, 2012 ).…”