2021
DOI: 10.2217/fvl-2020-0388
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Emerging Role for Pharmacogenomics in HIV Research in Africa

Abstract: Tweetable abstract Pharmacogenomics (Pgx); the study of how genes affect drug response may optimize treatment by improving effectiveness and safety of medications. To apply current guidelines for African HIV-infected patients Pgx research is key.

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“…Particularly, the article by Ragia et al emphasizes the significance of implementing DPYD genotyping in Greek cancer patients receiving fluoropyrimidine-based chemotherapy. This article underlines the role of genetic variants in different populations, not considering only a global population (e.g., Caucasian): some genetic polymorphisms could have not an impact in some ethnicities, as reported for example, for abacavir and HLA-B*5701 in Sub-Saharan African population ( Zhou et al, 2021 ). This genetic polymorphism predicts which patients treated with abacavir are more likely to develop hypersensitivity reaction, which could be severe and potentially fatal ( Dean, 2012 ).…”
mentioning
confidence: 80%
“…Particularly, the article by Ragia et al emphasizes the significance of implementing DPYD genotyping in Greek cancer patients receiving fluoropyrimidine-based chemotherapy. This article underlines the role of genetic variants in different populations, not considering only a global population (e.g., Caucasian): some genetic polymorphisms could have not an impact in some ethnicities, as reported for example, for abacavir and HLA-B*5701 in Sub-Saharan African population ( Zhou et al, 2021 ). This genetic polymorphism predicts which patients treated with abacavir are more likely to develop hypersensitivity reaction, which could be severe and potentially fatal ( Dean, 2012 ).…”
mentioning
confidence: 80%