Emerging role for ERM proteins in cell adhesion and migration

Arpin, Monique; Chirivino, Dafne; Naba, Alexandra; Zwaenepoel, Ingrid

doi:10.4161/cam.5.2.15081

Cited by 222 publications

(231 citation statements)

References 77 publications

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“…That the cadherin/catenin complex functions in membrane-to-cortex attachment may explain why this complex is important for regulating macropinocytosis in contact-free protruding membranes (56), single-cell wound closure in Drosophila (57), and plasma membrane blebbing during early embryogenesis in zebrafish (58). Plasma membrane blebbing involves functional crosstalk between the cadherin/catenin complex and ezrin-radixin-moesin (ERM) proteins (58), which also mediate membrane-to-cortex attachment (59). Although the molecular events directly downstream of E-cadherin tension remain unclear, E-cadherin, and likely αE-catenin, may be involved in a ubiquitous tension-sensing mechanism that regulates cortical cytoskeleton activity as a function of cell shape, size, or membrane activity.…”

Section: Discussionmentioning

confidence: 99%

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

Borghi

Sorokina

Shcherbakova

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

536

554

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The authors note that that in the constructs EcadTSMod, EcadTSModΔcyto, and EcadTSModΔmTFP, the Förster resonance energy transfer (FRET) acceptor fluorophore was monomeric enhanced yellow fluorescent protein (mEYFP)-not Venus as was originally reported. The photophysical properties of mEYFP and Venus, including absorption spectra, emission spectra, and fluorescence quantum yields are highly similar, leading to negligible changes in the Förster radius with the FRET donor monomeric Teal Fluorescent Protein (mTFP) (1). This substitution thus does not affect the FRET data reported in the original manuscript or their interpretation. The protein mEYFP is based on EYFP (Clontech) with the addition of the mutation A206K to suppress dimerization (2). www.pnas.org/cgi

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Section: Discussionmentioning

confidence: 99%

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

Borghi

Sorokina

Shcherbakova

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

536

554

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“…36 The ezrin --RDX --moesin family members can regulate multiple cell functions, 37,38 such as cell shape maintenance, formation of microvilli, cell adhesion, cell migration and cell polarity. Mounting evidence suggests that the ezrin --RDX --moesin family members have an important role in tumour metastasis.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers

et al. 2011

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Emerging evidence has shown that aberrantly expressed microRNAs (miRNAs) are highly associated with tumour development and progression. However, little is known about the potential role of miRNAs in gastric cancer (GC) metastasis. In this study, miR-409-3p was found to be downregulated frequently in human GCs, and its expression was significantly associated with tumor-node-metastasis (TNM) stage and lymph node metastasis. Enforced expression of miR-409 in GC cells significantly reduced their migration and invasion in vitro and their capacity to develop distal pulmonary metastases and peritoneal dissemination in vivo. Moreover, we found that miR-409 exerted its function predominantly through the mature miR-409-3p, but not miR-409-5p. Microarray and bioinformatics analysis identified the pro-metastatic gene radixin (RDX) as a potential miR-409-3p target. Further studies confirmed that miR-409-3p suppressed the expression of RDX by directly binding to its 3 0 -untranslated region. Silencing of RDX by small interfering RNAs phenocopied the effects of miR-409 overexpression, whereas restoration of RDX in miR-409-overexpressed GC cells reversed the suppressive effects of miR-409. Taken together, these results demonstrate that miR-409 suppresses GC cell invasion and metastasis by directly targeting RDX and that patients with downregulated miR-409-3p are prone to lymph node metastasis.

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“…[33][34][35] In addition to their role in stable adhesion, these proteins are also important in cell migration and have consequently been found upregulated during wound healing and tumorigenesis. [35][36][37] The lower LAMC2, ITGA6, and EZR gene expressions in UC-associated dysplasia as described in cohort 1 have, to our knowledge, not been described previously. As they persistently have been found upregulated in CRC, the decreased expression seems to distinguish this premalignant state from both normal, inflamed, and cancerous tissue in the colon.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Analysis of Left-sided Colitis, Pancolitis, and Ulcerative Colitis-associated Dysplasia

Bjerrum

Nielsen

Riis

et al. 2014

Inflammatory Bowel Diseases

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Emerging role for ERM proteins in cell adhesion and migration

Cited by 222 publications

References 77 publications

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers

Transcriptional Analysis of Left-sided Colitis, Pancolitis, and Ulcerative Colitis-associated Dysplasia

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