Emerging research on methamphetamine

Maxwell, Jane Carlisle

doi:10.1097/01.yco.0000165592.52811.84

Cited by 110 publications

(80 citation statements)

References 38 publications

(5 reference statements)

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“…However, they may include: neurochemical changes in areas of the brain that are associated with learning, potentially affecting cognitive function, behaviour, motor activity and changes in avoidance responses (106); psychotic, physiological and behavioural/developmental effects that include violent behaviour, depression, irritability, hallucinations, mood swings, paranoia, mood and sleep disorders that are associated with exposure to, or use of, methamphetamine (75,(106)(107)(108)(109)(110); as well as effects associated with exposure to the range of chemicals present, that includes cancer and effects on respiratory, renal, hepatic, neurological, developmental and reproductive systems (5). Exposures by first-responders have resulted in chronic respiratory (including asthma and significantly decreased lung function), gastrointestinal, neurological and immune system effects (29,63,102,111).…”

Section: Chronic Effectsmentioning

confidence: 99%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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AbstractThe clandestine manufacture of methamphetamine in residential homes may represent significant hazards and exposures not only to those involved in the manufacture of the drugs but also to others living in the home (including children), neighbours and first responders to the premises. These hazards are associated with the nature and improper storage and use of precursor chemicals, intermediate chemicals and wastes, gases and methamphetamine residues generated during manufacture and the drugs themselves. Many of these compounds are persistent and result in exposures inside a home not only during manufacture but after the laboratory has been seized or removed. Hence new occupants of buildings formerly used to manufacture methamphetamine may be unknowingly exposed to these hazards. Children are most susceptible to these hazards and evidence is available in the literature to indicate that these exposures may result in immediate and long-term adverse health effects. The assessment of exposure within the home can be undertaken by measuring contaminant levels or collecting appropriate biological data from individuals exposed. To gain a better understanding of the available data and key issues associated with these approaches to the characterisation of exposure, a review of the published literature has been undertaken.

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Section: Chronic Effectsmentioning

confidence: 99%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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“…Methamphetamine has become widely available in urban, suburban and rural communities nationwide (Maxwell, 2005). Formerly a favored drug of white, male, blue-collar workers in Hawaii and western United States (US) in the early 1990s (NIDA, 2006), methamphetamine use has become increasingly common among younger adults (Springer et al, 2007) and among gay and bisexual men (Cochran et al, 2004;Thiede et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Profile of lifetime methamphetamine use among homeless adults in Los Angeles

Nyamathi

Dixon

Shoptaw

et al. 2008

Drug and Alcohol Dependence

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Although the dramatic rise of methamphetamine use in the general population has been welldocumented, little is known about methamphetamine use in the homeless population. This study examines self-reported methamphetamine use and its correlates among a sample of 664 urban homeless adults in Los Angeles. Over one-quarter of the overall sample, and 60% of whites, disclosed lifetime methamphetamine use. Less than 10% of African-Americans reported ever using methamphetamine. Approximately one-tenth of respondents reported current methamphetamine use; almost 90% of current users shared straws to snort methamphetamine and half used it daily. Logistic regression analysis in younger (18-39) and older (40+) respondents revealed that white ethnicity, Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

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“…It is estimated that 60 million people worldwide have abused amphetamine-type psychostimulants, including methamphetamine (METH; Maxwell, 2005). METH abuse results in selective damage to central monoamine systems.…”

Section: Introductionmentioning

confidence: 99%

Expression and Activity of Nitric Oxide Synthase Isoforms in Methamphetamine-Induced Striatal Dopamine Toxicity

Friend

Son

Keefe

et al. 2012

J Pharmacol Exp Ther

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Nitric oxide is implicated in methamphetamine (METH)-induced neurotoxicity; however, the source of the nitric oxide has not been identified. Previous work has also revealed that animals with partial dopamine loss induced by a neurotoxic regimen of methamphetamine fail to exhibit further decreases in striatal dopamine when re-exposed to methamphetamine 7-30 days later. The current study examined nitric oxide synthase expression and activity and protein nitration in striata of animals administered saline or neurotoxic regimens of methamphetamine at postnatal days 60 and/or 90, resulting in four treatment groups: Saline:Saline, METH:Saline, Saline:METH, and METH: METH. Acute administration of methamphetamine on postnatal day 90 (Saline:METH and METH:METH) increased nitric oxide production, as evidenced by increased protein nitration. Methamphetamine did not, however, change the expression of endothelial or inducible isoforms of nitric oxide synthase, nor did it change the number of cells positive for neuronal nitric oxide synthase mRNA expression or the amount of neuronal nitric oxide synthase mRNA per cell. However, nitric oxide synthase activity in striatal interneurons was increased in the Saline: METH and METH:METH animals. These data suggest that increased nitric oxide production after a neurotoxic regimen of methamphetamine results from increased nitric oxide synthase activity, rather than an induction of mRNA, and that constitutively expressed neuronal nitric oxide synthase is the most likely source of nitric oxide after methamphetamine administration. Of interest, animals rendered resistant to further methamphetamine-induced dopamine depletions still show equivalent degrees of methamphetamine-induced nitric oxide production, suggesting that nitric oxide production alone in response to methamphetamine is not sufficient to induce acute neurotoxic injury.

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Emerging research on methamphetamine

Cited by 110 publications

References 38 publications

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Profile of lifetime methamphetamine use among homeless adults in Los Angeles

Expression and Activity of Nitric Oxide Synthase Isoforms in Methamphetamine-Induced Striatal Dopamine Toxicity

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