Emerging Relationship Between the Gut Microbiota and Neurodegenerative Disorders

Iyer, Shreyas M.; Verma, Shreya; Marathe, Sandhya Amol; Tare, Meghana

doi:10.1007/978-981-97-4288-2_11

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Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases 2024

DOI: 10.1007/978-981-97-4288-2_11

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Emerging Relationship Between the Gut Microbiota and Neurodegenerative Disorders

Shreyas M. Iyer,

Shreya Verma,

Sandhya Amol Marathe

et al.

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2024

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Cited by 1 publication

References 92 publications

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Implications of Butyrate Signaling Pathways on the Motor Symptomatology of Parkinson’s Disease and Neuroprotective Effects—Therapeutic Approaches: A Systematic Review

Missiego-Beltrán,

Olalla-Álvarez,

González-Brugera

et al. 2024

IJMS

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Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by motor and non-motor symptoms. Emerging evidence suggests that gut microbiota alterations, specifically involving short-chain fatty acids (SCFAs) like butyrate, may influence PD pathogenesis and symptomatology. This Systematic Review aims to synthesize current research on the role of butyrate in modulating motor symptoms and its neuroprotective effects in PD, providing insights into potential therapeutic approaches. A systematic literature search was conducted in April 2024 across databases, including ScienceDirect, Scopus, Wiley, and Web of Science, for studies published between 2000 and 2024. Keywords used were “neuroprotective effects AND butyrate AND (Parkinson disease OR motor symptoms)”. Four authors independently screened titles, abstracts, and full texts, applying inclusion criteria focused on studies investigating butyrate regulation and PD motor symptoms. A total of 1377 articles were identified, with 40 selected for full-text review and 14 studies meeting the inclusion criteria. Data extraction was performed on the study population, PD models, methodology, intervention details, and outcomes. Quality assessment using the SYRCLE RoB tool highlighted variability in study quality, with some biases noted in allocation concealment and blinding. Findings indicate that butyrate regulation has a significant impact on improving motor symptoms and offers neuroprotective benefits in PD models. The therapeutic modulation of gut microbiota to enhance butyrate levels presents a promising strategy for PD symptom management.

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Implications of Butyrate Signaling Pathways on the Motor Symptomatology of Parkinson’s Disease and Neuroprotective Effects—Therapeutic Approaches: A Systematic Review

Missiego-Beltrán,

Olalla-Álvarez,

González-Brugera

et al. 2024

IJMS

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Emerging Relationship Between the Gut Microbiota and Neurodegenerative Disorders

Cited by 1 publication

References 92 publications

Implications of Butyrate Signaling Pathways on the Motor Symptomatology of Parkinson’s Disease and Neuroprotective Effects—Therapeutic Approaches: A Systematic Review

Implications of Butyrate Signaling Pathways on the Motor Symptomatology of Parkinson’s Disease and Neuroprotective Effects—Therapeutic Approaches: A Systematic Review

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