Emerging or Underestimated Silica-Based Stationary Phases in Liquid Chromatography

Sobańska, Anna W.

doi:10.1080/10408347.2020.1760782

Cited by 7 publications

(4 citation statements)

References 185 publications

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Section: Facing the Challenges In The Isolation Of Hydrophilic Compoundsmentioning

confidence: 99%

“…1). It has been recently stated that the use of such stationary phases has been largely underestimated for liquid chromatography separations, 244 even though reports on properties and versatile applications of amino-, cyano-and diolbonded Si-gel stationary phases were available for decades. [245][246][247][248][249] In our 1996-2009 survey of 4859 articles reporting the isolation of natural products, 34 articles (0.7%) reported the use of an aminopropyl-derivatized Si-gel column in at least one of the separation steps.…”

Section: Ion-exchange Chromatographymentioning

confidence: 99%

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The isolation of water-soluble natural products – challenges, strategies and perspectives

et al. 2022

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Section: Facing the Challenges In The Isolation Of Hydrophilic Compoundsmentioning

confidence: 99%

Section: Ion-exchange Chromatographymentioning

confidence: 99%

The isolation of water-soluble natural products – challenges, strategies and perspectives

et al. 2022

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“…As a result, a great deal of work has been carried out on the enantioseparation of racemic drugs by applying different varieties of CSPs, which are grouped into eight catagories, as shown in Table 3 . Overviews of different separation principles and various applications of CSPs are given in [ 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Enantioseparation Of β-Blockers By Hplcmentioning

confidence: 99%

Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

et al. 2021

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β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).

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“…Spherical silica is one of the most important and widely used materials in the world, used as a simple additive in products such as toothpaste and cement (Mason et al 2019;Zheng et al 2020), and in more advanced applications such as drug delivery, chromatography, and sensors (Walcarius 2018;Manzano and Vallet-Regí 2020;Sobańska 2020). The production methods (Stöber and modified-Stöber) combined with the industrial scale at which spherical silica is made, is inherently environmentally unsustainable.…”

Section: Introductionmentioning

confidence: 99%

Spherical silica particle production by combined biomimetic-Stöber synthesis using renewable sodium caseinate without petrochemical agents

et al. 2021

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Spherical silica particles are typically made via Stöber processes. However, these processes are environmentally unsustainable. Here, we report a process to synthesise spherical silica particles in a more sustainable way using sodium caseinate. Initial experiments showed that sodium caseinate can replace the typical industrial structural directing agents used to produce spherical particles. Particles of 124 nm in size were produced with 200 mg L −1 sodium caseinate and 81 µL sodium silicate, and particles with a bimodal size distribution (258 and 1432 nm) were produced with 400 mg L −1 sodium caseinate and 81 µL sodium silicate. Particles with multimodal size distributions between 363-1588 nm and 342-860 nm where produced with 200 mg L −1 sodium caseinate and 162 µL sodium silicate and 200 mg L −1 sodium caseinate and 810 µL sodium silicate, respectively. Higher concentrations of sodium caseinate and low concentrations of sodium silicate promoted Ostwald ripening. Low concentrations of sodium caseinate and high concentrations of sodium silicate promoted coalescence. Subsequent optimisation of the monodispersity using a statistical design of experiments yielded size-monodisperse silica particles with a narrower size distribution between 172 and 340 nm using sodium caseinate, calcium chloride, sodium silicate, and acetate buffer. Analysis of variance (ANOVA) and regression analyses were used to determine and quantify the relationship between reagent concentrations and particle size. A regression equation was calculated, which predicts particle size based on reagent concentration. Predicted particle sizes (189.6, 197.1, 204.6, and 212.1 nm) and experimentally determined particle sizes (200, 190, 184, and 196 nm) showed good agreement. The possibility of producing spherical silica particles sustainably is shown.

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Emerging or Underestimated Silica-Based Stationary Phases in Liquid Chromatography

Cited by 7 publications

References 185 publications

The isolation of water-soluble natural products – challenges, strategies and perspectives

The isolation of water-soluble natural products – challenges, strategies and perspectives

Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

Spherical silica particle production by combined biomimetic-Stöber synthesis using renewable sodium caseinate without petrochemical agents

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