Emerging non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes causing adult invasive pneumococcal disease in the late-PCV13 period in Spain

González-Díaz, Aida; Càmara, Jordi; Ercibengoa, María; Cercenado, Emilia; Larrosa, Nieves; Quesada, María Dolores; Fontanals, Dionísia; Cubero, Meritxell; Marimón, José María; Yuste, José; Ardanuy, Carmen

doi:10.1016/j.cmi.2019.10.034

Cited by 41 publications

(29 citation statements)

References 33 publications

(43 reference statements)

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“…In 2005, the emergence of a penicillin-and amoxicillin-resistant serotype 11A lineage related to CC156 was identified [10]. In our setting, serotype 11A isolates related to the CC156 clone were the leading cause of β-lactam resistance in the years 2015 and 2016 [12]. Nowadays, in Spain, there are two main serotype 11A sequence types (ST) derived from CC156: ST838, first detected in 2005, which is a single locus variant (SLV) of ST156; and ST6521 which is a double locus variant (DLV) of ST156 emerged in 2009 [10].…”

Section: Introductionmentioning

confidence: 72%

Two multi-fragment recombination events resulted in the β-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016

et al. 2020

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Section: Introductionmentioning

confidence: 72%

Two multi-fragment recombination events resulted in the β-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016

et al. 2020

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“…However, no analyses have been performed to confirm this observation. A high prevalence of non-PCV13 serotypes has previously been described in the Gambia [ 19 ], Malawi [ 37 ] and Tanzania [ 38 ] probably due to serotype replacement following PCV introduction as observed in many countries [ 19 , 39 , 40 ]. The geographic disparity of pneumococcal carriage around the world may contribute to this phenomenon [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

High bacterial and viral load in the upper respiratory tract of children in the Democratic Republic of the Congo

et al. 2020

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Background Respiratory pathogens including Streptococcus pneumoniae and Haemophilus influenzae , are implicated in the pathogenicity of acute lower respiratory infection (ALRI). These are also commonly found in both healthy and sick children. In this study, we describe the first data on the most frequent bacteria and viruses detected in the nasopharynx of children from the general population in the Eastern DR Congo. Methods From January 2014 to June 2015, nasopharyngeal samples from 375 children aged from 2 to 60 months attending health centres for immunisation or growth monitoring were included in the study. Multiplex real-time PCR assays were used for detection of 15 different viruses and 5 bacterial species and for determination of pneumococcal serotypes/serogroups in the nasopharyngeal secretions. Results High levels of S. pneumonia e were detected in 77% of cases, and H . influenzae in 51%. Rhinovirus and enterovirus were the most commonly found viruses, while respiratory syncytial virus (RSV) was rare (1%). Co-occurrence of both bacteria and viruses at high levels was detected in 33% of the children. The pneumococcal load was higher in those children who lived in a dwelling with an indoor kitchen area with an open fire, i.e. a kitchen with an open fire for cooking located inside the dwelling with the resultant smoke passing to the living room and/or bedrooms; this was also higher in children from rural areas as compared to children from urban areas or children not living in a dwelling with an indoor kitchen area with an open fire/not living in this type of dwelling. Immunization with 2–3 doses of PCV13 was associated with lower rates of pneumococcal detection. Half of the identified serotypes were non-PCV13 serotypes. The most common non-PCV13 serotypes/serogroups were 15BC, 10A, and 12F, while 5, 6, and 19F were the most prevalent PCV13 serotypes/serogroups. Conclusions The burden of respiratory pathogens including S. pneumonia e in Congolese children was high but relatively few children had RSV. Non-PCV13 serotypes/serogroups became predominant soon after PCV13 was introduced in DR Congo.

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“…The herd effect of childhood vaccination on adults may be jeopardised due to an increase in disease by non-vaccine serotypes, as exemplified in a recent study [ 28 ]. In the current cohort, serogroup 15 was common among non-PCV13 types in adult disease.…”

Section: Discussionmentioning

confidence: 99%

Persistence of Pneumococcal Serotype 3 in Adult Pneumococcal Disease in Hong Kong

et al. 2021

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The epidemiology of hospitalised pneumococcal disease in adults following the introduction of universal childhood pneumococcal immunisation in 2009 was assessed. Culture-confirmed Streptococcus pneumoniae (SP) from adults hospitalised between 2009 to 2017 were examined. The cases were categorised into invasive pneumococcal disease (IPD) and pneumonia (bacteraemic, non-bacteraemic, and that associated with other lung conditions). The isolates were serotyped and antimicrobial susceptibilities were determined by microbroth dilution. Patient characteristics, comorbidities, and outcomes were analysed. Seven hundred and seventy-four patients (mean age, 67.7 years, SD ± 15.6) were identified, and IPD was diagnosed in 110 (14.2%). The most prevalent serotype, 19F, was replaced by serotype 3 over time. Penicillin and cefotaxime non-susceptibilities were high at 54.1% and 39.5% (meningitis breakpoints), 19.9% and 25.5% (non-meningitis breakpoints), respectively. The overall 30-day mortality rate was 7.8% and 20.4% for IPD. Age ≥ 75 years (OR:4.6, CI:1.3–17.0, p < 0.02), presence of any complications (OR:4.1, CI:1.02–16.3, p < 0.05), pleural effusion (OR:6.7, CI:1.2–39.4, p < 0.03) and intensive care unit (ICU) admission (OR:9.0, CI:1.3–63.4, p < 0.03) were independent predictors of 30-day mortality. Pneumococcal disease by PCV 13 covered serotypes; in particular, 19F and 3 are still prominent in adults. Strengthening targeted adult vaccination may be necessary in order to reduce disease burden.

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Emerging non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes causing adult invasive pneumococcal disease in the late-PCV13 period in Spain

Cited by 41 publications

References 33 publications

Two multi-fragment recombination events resulted in the β-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016

Two multi-fragment recombination events resulted in the β-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016

High bacterial and viral load in the upper respiratory tract of children in the Democratic Republic of the Congo

Persistence of Pneumococcal Serotype 3 in Adult Pneumococcal Disease in Hong Kong

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