Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease

Sun, Mengchi; Ban, Weiyue; Ling, Hao; Yu, Xiang; Zhang, He; Jiang, Qikun; Sun, Jin

doi:10.1016/j.cclet.2022.03.061

Cited by 22 publications

(9 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TextBoxes text detection method is composed of two parts, one is the TextBoxes network and the other is the nonmaximum suppression algorithm (NMS) [10] . The TextBoxes network is a convolutional neural network based on forward propagation, which is used to predict the text area in the image, and finally get the candidate text box.…”

Section: Textboxes Character Detection Methodsmentioning

confidence: 99%

Research on stamped character detection system based on TextBoxes

Hao,

Cai,

Dong

et al. 2023

5th International Conference on Information Science, Electrical, and Automation Engineering (ISEAE 2023)

View full text Add to dashboard Cite

In order to realize the rapid detection of stenciled characters on castings in the industrial site, and to better classify and manage the castings, under the influence of complex environmental factors on the industrial site, the stenciled characters of castings have the characteristics of low contrast and inconspicuous edge features, etc., using deep learning. Methods An end-to-end OCR (Optical Character Recognition) casting steel stamp character recognition system was designed. By using the improved TextBoxes detection method on the input image to locate the target character area, combined with the CRNN (Convolutional Recurrent Neural Network) character recognition method to recognize and output the detected stamped characters, and at the same time augment the image data to improve the recognition accuracy. The results show that the model can reach 98.9% in recognition accuracy, and the average inspection time is 0.27S. It is superior to traditional template matching methods and other current mainstream deep learning target detection algorithms in recognition accuracy and speed. In terms of processing natural language information. It provides convenience and provides an effective means of human-computer interaction.

show abstract

Section: Textboxes Character Detection Methodsmentioning

confidence: 99%

Research on stamped character detection system based on TextBoxes

Hao,

Cai,

Dong

et al. 2023

5th International Conference on Information Science, Electrical, and Automation Engineering (ISEAE 2023)

View full text Add to dashboard Cite

show abstract

“…Therefore, there is a growing interest in combining drug delivery methods with the microbiome domain to enhance probiotic delivery. − Various innovative materials, such as liposomes, polymer gels, − polymer micelles, bacterial biofilms, , and cell membranes, have been studied to overcome these obstacles during the oral delivery of probiotics. However, these efforts have only focused on protecting probiotics from GI damage under physiological conditions, ignoring the fact that the pathological condition of colitis can also severely impede the colonization of probiotic. − Notably, IBD is frequently associated with dysbiosis and is characterized by alterations in the intestinal microbial community, including the expansion of Enterobacteriaceae. − In disease states, the massive occupation of ecological niches by Enterobacteriaceae severely restricts the colonization of probiotics. Thus, achieving efficient colonization by disrupting the ecological niche of harmful bacteria presents a formidable challenge .…”

Section: Introductionmentioning

confidence: 99%

Calcium Tungstate Microgel Enhances the Delivery and Colonization of Probiotics during Colitis via Intestinal Ecological Niche Occupancy

et al. 2023

View full text Add to dashboard Cite

The effective delivery and colonization of probiotics are recommended for therapeutic interventions during colitis, the efficacy of which is hampered by abnormally colonized Enterobacteriaceae at pathological sites. To improve the delivery and colonization of probiotics, a calcium tungstate microgel (CTM)based oral probiotic delivery system is proposed herein. CTM can selectively disrupt the ecological niche occupied by abnormally expanded Enterobacteriaceae during colitis to facilitate probiotic colonization. In addition, the calcium-binding protein, calprotectin, which is highly expressed in colitis, efficiently extracts calcium from CTM and releases tungsten to inhibit Enterobacteriaceae by displacing molybdenum in the molybdenum enzyme, without affecting the delivered probiotics. Moreover, CTM demonstrated resistance to the harsh environment of the gastrointestinal (GI) tract and to intestinal adhesion. The synergistic reduction of Enterobacteriaceae by 45 times and the increase in probiotic colonization by 25 times, therefore, result in a remarkable treatment for colitis, including restoration of colonic length, effective downregulation of the inflammatory response, restoration of the damaged mucosal barrier, and restoration of gut microbiome homeostasis.

show abstract

“…Ulcerative colitis is a chronic, idiopathic inflammatory bowel disease that is characterized by debilitating clinical symptoms, including diarrhea, hematochezia, abdominal pain, and weight loss. [1,2] Despite notable advances in the development of immunosuppressants, antibiotics, and corticosteroids for treating ulcerative colitis, these drugs are often associated with limited efficacy, drug resistance, and severe side effects. [3,4] Consequently, the increasing incidence and high recurrence rate of ulcerative colitis poses significant physical and economic burdens on patients, underscoring the urgent need to develop effective drug delivery systems with improved therapeutic efficacy and reduced side effects.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis

Wang,

Xiang,

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Ulcerative colitis is a chronic inflammatory bowel disease with a high recurrence rate. Natural phytochemical compounds are increasingly being considered as preventative and supportive treatments for this condition. However, the poor water solubility and stability of many of these compounds limit their effectiveness in vivo. To address this issue, fisetin (FT), a natural phytochemical with poor solubility, was stabilized using silk sericin (SS) to create a composite (SS/FT). The therapeutic potential of the SS/FT on ulcerative colitis was extensively investigated, and the results showed that it effectively alleviated the body weight loss and colon length shortening induced by dextran sulfate sodium. Notably, SS/FT downregulated the immune response, decreased colonic histopathological lesions, and reduced the cGAS/STING signal activation. This suggests that SS/FT may offer a promising therapy for treating ulcerative colitis.This article is protected by copyright. All rights reserved

show abstract

Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease

Cited by 22 publications

References 137 publications

Research on stamped character detection system based on TextBoxes

Research on stamped character detection system based on TextBoxes

Calcium Tungstate Microgel Enhances the Delivery and Colonization of Probiotics during Colitis via Intestinal Ecological Niche Occupancy

Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis

Contact Info

Product

Resources

About