Emerging low-molecular weight nucleopeptide-based hydrogels: state of the art, applications, challenges and perspectives

Giraud, Tristan; Hoschtettler, Paul; Pickaert, Guillaume; Averlant‐Petit, Marie‐Christine; Stefan, Loïc

doi:10.1039/d1nr06131c

Cited by 23 publications

(26 citation statements)

References 109 publications

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“…The higher peptide yield indicated that the hydrolysis was more effective, thereby more peptides with lower molecular weight were formed. Numerous studies have reported that the peptides with lower molecular weight exhibited stronger bioactivity as compared with proteins. , Moreover, our preliminary in vitro experiments have confirmed that there was an inverse relationship between the molecular weight and the activity of the peptides. Thus, in this study, the yield and molecular weight of the peptides were chosen to be indicators as the preparation of Se-EWP.…”

Section: Resultssupporting

confidence: 74%

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Chen

Zhang

et al. 2022

J. Agric. Food Chem.

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Selenium-enriched egg white peptides (Se-EWP) were prepared by pre-heat treatment and enzymatic hydrolysis in this study. In addition, their selenopeptide sequence identification and immunomodulatory effect were investigated. Results showed that the yield of Se-EWP obtained from alkaline–neutral protease treatment reached 76.90%, and peptides with a molecular weight of 200–1000 Da accounted for 98.33%. Four characteristic selenopeptides, including SeCys-Trp-Leu-Glu, Trp-Ser-SeCys, SeMet-Ala-Pro, and SeMet-Leu, were identified by HPLC–ESI-MS/MS, which were rich in hydrophobic and branched-chain amino acids. Se-EWP (750 mg/kg/d) could effectively retard the decrease of immune organ index in immunosuppressed mice induced by cyclophosphamide. Moreover, supplementation of Se-EWP could promote a higher content of Se in liver, the number of white blood cells, and the levels of serum cytokines (IL-6, IL-2, and TNF-α) as compared with EWP groups, indicating that Se-EWP could effectively alleviate immunosuppression induced by cyclophosphamide. These findings suggested that Se-EWP exhibited great potential as functional foods for immunomodulatory effect.

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Section: Resultssupporting

confidence: 74%

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Chen

Zhang

et al. 2022

J. Agric. Food Chem.

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“…The nucleobase-bearing short peptide-based supramolecular structures have natural ability to self-assemble via non-covalent interactions. Supramolecular hydrogels offer specific benefits, such as modularity, tunability, bottom-up design, extracellular matrix-like structure, biomimicry, responsiveness to physical, mechanical, chemical or biological stimuli ( Scognamiglio et al, 2021 ; Giraud et al, 2022 ). Hence, they are suitable for inter alia drug delivery ( Noblett et al, 2021 ).…”

Section: Landscape Of Opportunities: Topical Insightsmentioning

confidence: 99%

“…Hence, they are suitable for inter alia drug delivery ( Noblett et al, 2021 ). Other innovative applications of nucleopeptides will appear in the next years, due to their appealing features such as reduced cytotoxicity or precise control of the properties ( Giraud et al, 2022 ).…”

Section: Landscape Of Opportunities: Topical Insightsmentioning

confidence: 99%

Smart therapies against global pandemics: A potential of short peptides

et al. 2022

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BackgroundAs we entered the third year of this pandemic, since the World Health Organisation (WHO) declared in March 2020 the novel coronavirus severe acute respiratory syndrome (SARS-CoV2) outbreak as a global pandemic COVID-19 (COronaVIrus Disease 19), we are still fighting with newer and newer viral mutations. The pandemic has passed the grim milestone of over 6.4 million COVID19 deaths, from more than 550 million reported cases thus far. In fact, more than 15 million people can die by the end of this year. It is highly likely that this pandemic will become endemic, while the full evolutionary potential of coronaviruses has yet to be revealed. The next pandemic is coming. A microbe with features of SARS-Middle East respiratory syndrome (MERS) and SARS-CoV-2 could lead to significantly more catastrophic loss of life. The co-evolution with other viruses should not be neglected. According to the WHO, we should expect diverse zoonotic, outbreakprone microbes, including highly pathogenic strains of influenza, Nipah, Ebola, Zika, or hemorrhagic fever viruses. 'It's an evolutionary certainty that there will be another virus with the potential to be more transmittable and deadly than this one', said Tedros Adhanom Ghebreyesus, director-general of the WHO. On the other hand, in both poor countries and regions of armed conflict, where vaccination is hampered, historic diseases are re-emerging, with migration and displacement influencing transmission risk and limiting control, and raising potential for additional outbreaks. Furthermore, there are other looming terrible threats to humanity as damaging as the bubonic plagues, such as bioterrorism or antibiotic resistant microorganisms. In most cases, both effective prevention and treatment options are limited.

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“…But the problem of finding this line remains difficult, especially when one is dealing with a nitrogen atom embedded in an environment that is not fully rigid. This is precisely the problem addressed here in hydrogels formed by nucleobase-containing peptides (also termed nucleopeptides) . In such hydrogels, it may happen that a given NH grouping of a nucleobase is partly immobilized and then able to produce NQR peaks at unpredictable frequencies due to the labile character of the NH grouping.…”

Section: Introductionmentioning

confidence: 98%

On the Observation of ¹⁴N Quadrupole Resonance Transitions in Water Proton NMR Relaxometry Dispersion Curves: The Case of a Labile NH Grouping in a Semirigid Molecular Moiety

et al. 2022

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The electric field gradient tensor (considered here at the level of a nitrogen nucleus) can be described by two parameters: the largest element in the (X,Y,Z) principal axis system, denoted by VZZ (leading to the nuclear quadrupole coupling), and the asymmetry parameter η = (|VYY | – |VXX |)/|VZZ | with |VZZ | > |VYY | > |VXX |. The frequencies of the three nitrogen-14 nuclear quadrupole resonance (NQR) transitions depend on both parameters but, for sensitivity reasons, their determination may be especially difficult and time consuming. For a partly rigid NH grouping with a labile proton, water nuclear magnetic resonance (NMR) relaxometry curves may exhibit these three transitions (dubbed quadrupolar dips or quadrupole relaxation enhancement (QRE)), provided that the NH grouping belongs to a moiety possessing a sufficient degree of ordering. Their line shape leads to the correlation time describing mainly the motion of the NH grouping (the proton of which being in exchange with water protons), and their amplitude can be interpreted in terms of an effective NH distance. This approach is applied to a hydrogel, where separate NQR lines are observed for the different types of water existing in this system. Furthermore, the analysis of experimental data allows one to determine the nuclear quadrupole coupling in the protonated and deprotonated forms of this molecular moiety involving a labile NH grouping.

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Emerging low-molecular weight nucleopeptide-based hydrogels: state of the art, applications, challenges and perspectives

Abstract: Over the last twenty years, low-molecular weight gelators and, in particular, peptide-based hydrogels, have drawn great attention of scientists thanks to both their inherent advantages in terms of properties and...

Cited by 23 publications

References 109 publications

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Smart therapies against global pandemics: A potential of short peptides

On the Observation of ¹⁴N Quadrupole Resonance Transitions in Water Proton NMR Relaxometry Dispersion Curves: The Case of a Labile NH Grouping in a Semirigid Molecular Moiety

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Emerging low-molecular weight nucleopeptide-based hydrogels: state of the art, applications, challenges and perspectives

Abstract: Over the last twenty years, low-molecular weight gelators and, in particular, peptide-based hydrogels, have drawn great attention of scientists thanks to both their inherent advantages in terms of properties and...

Cited by 23 publications

References 109 publications

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White

Smart therapies against global pandemics: A potential of short peptides

On the Observation of 14N Quadrupole Resonance Transitions in Water Proton NMR Relaxometry Dispersion Curves: The Case of a Labile NH Grouping in a Semirigid Molecular Moiety

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On the Observation of ¹⁴N Quadrupole Resonance Transitions in Water Proton NMR Relaxometry Dispersion Curves: The Case of a Labile NH Grouping in a Semirigid Molecular Moiety