Emerging landscape of circFNDC3B and its role in human malignancies

Abstract

In recent years, more attention has been paid to expanding the abundance of Circular RNAs (circRNAs), while the circRNAs that have been found to have significant functions have not been studied in different diseases. CircFNDC3B is one of the most researched circRNAs generated from fibronectin type III domain-containing protein 3B (FNDC3B) gene. Accumulating researches have reported the multiple functions of circFNDC3B in different cancer types and other non-neoplastic diseases, and predicted that circFNDC3B might be a potential biomarker. Notably, circFNDC3B can play roles in different diseases by binding to various microRNAs (miRNAs), binding to RNA-binding proteins (RBPs), or encoding functional peptides. This paper systematically summarizes the biogenesis and function of circRNAs, reviews and discusses the roles and molecular mechanisms of circFNDC3B and its target genes in different cancers and non-neoplastic diseases, which will do favor to broaden our comprehension of the function of circRNAs and facilitate subsequent research on circFNDC3B.

A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc

“…We ultimately identified 11 circFNDC3B candidates that capable of translating proteins among 65 circFNDC3Bs via circRNADb and TransCirc database. Among the top five candidates, hsa_circ_0001361 and hsa_circ_0006156 have been reported in oral cancer and colon cancer [ 12 ], and the primers for hsa_circ_0006948 and hsa_circ_0005700 were not successfully designed. Therefore, we selected circ0003692 for intensive study (Additional file 1: Table S7 , Fig.…”

“…CircFNDC3B, derived from the gene FNDC3B, stands as one of the extensively studied circRNAs. Fourteen studies have investigated the diverse functions of circFNDC3B in various diseases [ 12 ]. For example, Hong et al demonstrated that circFNDC3B promoted the migration and invasion of GC cells by regulating the expression of E-cadherin and CD44 [ 13 ].…”

“…Currently, the functional mechanisms of circRNA encompass several aspects, including acting as a miRNA sponge [ 11 , 12 ], binding to RNA binding proteins (RBPs) [ 14 ] or translating protein [ 15 ]. Recently, there has been significant emphasis on translational circRNA to determine its clinical significance [ 16 ].…”

Prospects for the clinical application of exosomal circular RNA in squamous cell carcinoma

“…further revealed that the high expression of circFNDC3B in serum exosomes is directly associated with the occurrence and development of esophageal squamous cell carcinoma, possibly serving as an independent risk predictor for aiding in early diagnosis ( 29 ). CircfNDC3B not only affects tumor cells through exosomal transfer but also functions through the miR-490–5p/TXNRD1 axis, further driving the progression of esophageal squamous cell carcinoma ( 30 ). Transfection of exosomal circ-CYP24A1 can inhibit the malignant behavior of cutaneous squamous cell carcinoma, offering new possibilities for noninvasive therapeutic strategies and potentially serving as a diagnostic marker ( 31 ).…”

The emerging role of circular RNAs in cisplatin resistance in ovarian cancer: From molecular mechanism to future potential

“…Unlike linear RNAs, circRNAs have a steady, conserved, covalent loop structure and are resistant to degradation by exonuclease in the cytoplasm due to having a unique continuous loop structure and not having 3′ and 5’ ends [ 85 ]. Because of their high stability, circRNAs are known as biomarkers for diagnosis, prognosis, and prediction of response to treatment in body fluids (urine, plasma, exosomes, etc.)…”