Emerging issues in the environmental context of antibiotic-resistance

Petrillo, Jessica E.; Ogunseitan, Oladele A.

doi:10.1016/j.envint.2018.03.049

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…12 A major strength of the NAP is that it was developed on the One Health (OH) approach, and involved a collaborative effort of stakeholders from multiple disciplines in the human, environment, and animal sectors. [13][14][15] Zoonotic and environmental pathogens have caused dire health consequence to human populations. The overuse of antibiotics as prophylactics in animal husbandry complicates the problem of antibiotic resistance as resistant bacteria can be transmitted from animals to humans through contaminated food and unsafe handling of sick animals, 16,17 thus reiterating the necessity of the OH approach.…”

Section: Conclusion Conclusionmentioning

confidence: 99%

National Action Plan on Antimicrobial Resistance: stakeholder analysis of implementation in Ghana

Jimah

Ogunseitan

2020

Journal of Global Health Reports

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Background Background Understanding potential barriers to implementation of public health policy is important to ensure well-informed decisions, and stakeholders play critical roles in implementation. Stakeholder analysis is expected to shed light on Ghana's progress with the implementation of the National Action Plan on Antimicrobial Resistance since the completion of the Global Health Security Agenda's Joint External Evaluation. The outcome of stakeholder analysis can improve understanding of their roles and institutional capacity to promote prudent use of antibiotics in populations at the community level. Methods Methods Eight semi-structured in-depth interviews were conducted with participants of the Joint External Evaluation process, including personnel from the policy, research, and practice programs in Ghana's public health sector. In-person interviews were conducted between September and October 2018 in the Greater Accra and Upper West regions.

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Section: Conclusion Conclusionmentioning

confidence: 99%

National Action Plan on Antimicrobial Resistance: stakeholder analysis of implementation in Ghana

Jimah

Ogunseitan

2020

Journal of Global Health Reports

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“…In addition, surveillance of ARGs in environmental samples and compilation of evidence-based information about the significance and magnitude of the potential impacts of ARGs in health and food security contexts at international level must also be encouraged (Berendonk et al, 2015;Petrillo and Ogunseitan, 2018). The current lack of an standardize characterization and quantification procedure of ARGs applicable to environmental samples due the highly diverse and abundant soil microbiome (Ju et al, 2016) is the reason why there are scarce the detailed dose-response data useful for ecological risk assessment of ARGs introduced after the amendment of soils with organic wastes.…”

Section: Contaminants Of Emerging Concern In Soils Amended With Organic Wastes and The Road Aheadmentioning

confidence: 99%

How Valuable Are Organic Amendments as Tools for the Phytomanagement of Degraded Soils? The Knowns, Known Unknowns, and Unknowns

Gómez-Sagasti

Hernández

Artetxe

et al. 2018

Front. Sustain. Food Syst.

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Nowadays, soil functionality and productivity are severely impaired due, in great part, to the fact that most of the land is being intensively used for food production and urbanization purposes, with a consequent rise in the generation of wastes and consumption/degradation of fertile soils. These issues can be jointly addressed by an integrated and sustainable management of the soil resource carried out in the framework of two recent paradigms: circular economy and phytomanagement. Within the fields of resource conservation and regenerative (urban) land management, at least the three following fundamental aspects can be contemplated: (i) the valorization and safe recovery of organic wastes (e.g., composts, green and animal manures, and biosolids) as soil amendments (from residue to resource); (ii) the re-development and revegetation of degraded soils characterized by low organic matter content, deficient physical structure and depressed biological status (from bare to vegetated soil); and, finally, (iii) the promotion of soil health in order to support soil ecological processes, functions and concomitant ecosystem services (integration of ecocentric and anthropocentric perspectives). Here, we discuss the benefits (knowns), potential risks (known unknowns) and future/affordable uncertainties (unknowns) resulting from the application of organic amendments (OAs) to soil. Traditionally, most studies have used physical-chemical parameters to assess soil health/quality, whereas less attention has been paid to soil biological criteria. Thus, we highlight the relevance of soil biological properties as key drivers of ecological restoration and suitable indicators of soil health. Notwithstanding, special attention should be paid to "amendments-plants-microorganisms" interactions in different soils and field conditions. Finally, the risk of introduction of emerging contaminants, including for instance microplastics and antibiotic resistance genes (ARGs), through the application of OAs to soil, is currently a matter of much concern that must urgently be addressed if we are to continue with such practice.

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“…For several decades, antimicrobial resistance has been a growing threat to the treatment of the rising range of infections caused by bacteria (World Health Organization [WHO], 2014). It is predicted that mortality due to drug‐resistant diseases will become a leading cause of the future global challenge (Kumar et al, 2020; Petrillo & Ogunseitan, 2018). The main parts of the antibiotics consumed by humans and animals are not always metabolized completely and excreted in human and animal feces, which eventually end up in wastewater and finally, through the effluent discharges, may find their way into the water bodies (Cacace et al, 2019; Guo et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Characterization of antibiotic resistance genes and bacteria in a municipal water resource recovery facility

Rajabi

Farajzadeh

Dehghanzadeh

et al. 2022

Water Environment Research

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Municipal water resource recovery facilities (WRRFs) are important sources of antibiotic‐resistant bacteria and genes (ARB and ARGs). In this study, antibiotic‐resistant total heterotrophic bacteria (THBR) counts (CFU/ml) cultivated from influent, effluent of activated sludge process, and outflow of disinfection unit of an urban WRRF were investigated for the presence of 16, 32, 64, and 128 μg/ml of nine antibiotics. The isolates of Pseudomonas spp., Acinetobacter spp., and Escherichia coli obtained from effluent of activated sludge process were subjected for molecular identification by detecting the 16S rRNA gene sequences. Additionally, using the polymerase chain reaction method (PCR), the isolates were investigated for the presence of blaSHV, blaTEM, blaCTX‐M, blaVIM, sul1, and qnrS genes. According to the results, the abundance of THBR counts was not significantly reduced by the biological treatment except for cefixime and sulfamethoxazole; it also increased for some antibiotics after disinfection unit. The average removal efficiency of THBR resistant to ciprofloxacin, sulfamethoxazole, and ceftazidime were 7.9 ± 1.7%, 41.8 ± 2.1%, and 14.4 ± 6.2%, respectively. Also, all the tested isolates were resistant to at least four antibiotics. For all antibiotics, the resistance ratio (THBR/THB) significantly increased in the effluent and after chlorination unit. Among 12 resistant isolates, blaTEM and sul1 genes were the most frequently detected ones involved in 92% and 83% of the isolates, respectively. Both blaTEM and sul1 genes were found in 100% of E. coli, and 83% and 67% of Pseudomonas spp. isolates, respectively. Further efforts are necessary to limit the transmission of ARB and ARGs from WRRFs into the environment and prevent human health threats. Practitioner Points The ratio of resistance significantly increased after biological treatment. Up to 40% of heterotrophic bacteria in the effluent was antibiotic resistant. blaTEM and sul1 genes were more prevalent (92%) in all isolates of bacteria. Both blaTEM and sul1 genes were found in 100% of E. coli isolates. Pseudomonas spp. holds blaTEM and sul1 genes in 83% and 67% of isolates, respectively.

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Emerging issues in the environmental context of antibiotic-resistance

Cited by 7 publications

References 7 publications

National Action Plan on Antimicrobial Resistance: stakeholder analysis of implementation in Ghana

National Action Plan on Antimicrobial Resistance: stakeholder analysis of implementation in Ghana

How Valuable Are Organic Amendments as Tools for the Phytomanagement of Degraded Soils? The Knowns, Known Unknowns, and Unknowns

Characterization of antibiotic resistance genes and bacteria in a municipal water resource recovery facility

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