Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia

Mayne, Peter

doi:10.2147/ijgm.s27336

Cited by 37 publications

(53 citation statements)

References 13 publications

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“…Duration: 8 yearsDiagnosed with fibromyalgia at 17 yrs ldLyme serology IgG titre 80 and IgM titre 10.NP/NP[79]Mid-north coast of NSWTravelled from Byron Bay NSW to Eastlakes Victoria. No overseas travel.Lyme-like presentationLyme IgM western blot bands 23–25, 39 and 41 kDa. B. henselae IgM serology positive (titre 1:40).NP/NP[80]QLDTravelled to northern NSW and Sydney, NSW; Melbourne, Victoria; Hobart, Tasmania. No overseas travel.Lyme-like presentationLyme IFA 1:40.…”

Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

“…Babesia duncani IgG serology positive 1:40, Babesia microti IgG serology positive 1:40, Bartonella henselae IgM serology positive 1:40.NP/positive (NS)[80]Armstrong beach, QLDKarratha, WA. No overseas travel.Lyme-like presentationLyme IFA serology 1:80, Lyme IgM western blot bands 34 and 41 kDa, Bartonella IgG serology positive 1:40.NP/negative[80]NSWVictoria, Queensland, South Australia. No overseas travel.Lyme-like presentationLyme IgM western blot bands 31 and 41 kDa.…”

Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

“…No overseas travel.Lyme-like presentationLyme IgM western blot bands 31 and 41 kDa. Babesia duncani IgG positive 1:40.NP/negative[80]ND, no data; NP, not performed; NS, not sequenced; EM, erythema migrans; ESR, erythrocyte sedimentation rate; PCR, polymerase chain reaction; EEG, electroencephalogram; CAT, computerized axial tomography; ECG, electrocardiogram; CSF, cerebrospinal fluid; RRV, Ross river virus; NT, northern territory; WA, western Australia; QLD, Queensland; NSW, New South Wales; VIC, Victoria; and TAS, Tasmania.aSerological confirmation of Lyme Borreliosis in the context of non-endemicity is questionable; diagnosis by culture and molecular identification methods are preferable for confirmation in the Australian setting.…”

Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

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Is there a Lyme-like disease in Australia? Summary of the findings to date

2016

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Lyme Borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the Borrelia burgdorferi sensu lato (B. burgdorferi s. l.) complex. It results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. In the last twenty-five years there have been over 500 reports of an Australian Lyme-like syndrome in the scientific literature. However, the diagnoses of Lyme Borreliosis made in these cases have been primarily by clinical presentation and laboratory results of tentative reliability and the true cause of these illnesses remains unknown. A number of animals have been introduced to Australia that may act as B. burgdorferi s. l. reservoirs in Lyme-endemic countries, and there are some Australian Ixodes spp. and Haemaphysalis spp. ticks whose geographical distribution matches that of the Australian Lyme-like cases. Four published studies have searched for Borrelia in Australian ticks, with contradicting results. The cause of the potential Lyme-like disease in Australia remains to be defined. The evidence to date as to whether these illnesses are caused by a Borrelia species, another tick borne pathogen or are due to a novel or unrelated aetiology is summarised in this review.

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Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

Section: Lyme-like Case Reported In Australiamentioning

confidence: 99%

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Is there a Lyme-like disease in Australia? Summary of the findings to date

2016

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“…One additional subject from Australia with no history of travel was reported to be positive by PCR for B. duncani . (33) His clinical presentation was not described in this publication.…”

Section: Resultsmentioning

confidence: 87%

“…The clinical syndromes from these patients were not described; their seropositivity to Bartonella was an isolated IgM titer of 1:40, and these subjects only had IgM seroreactivity to B. burgdorferi . (33)…”

Section: Resultsmentioning

confidence: 99%

Chronic Coinfections in Patients Diagnosed with Chronic Lyme Disease: A Systematic Review

Lantos

Wormser

2014

The American Journal of Medicine

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Purpose The controversial diagnosis of chronic Lyme disease is often given to patients with prolonged, medically unexplained physical symptoms. Many such patients are also treated for chronic co-infections with Babesia, Anaplasma, or Bartonella in the absence of typical presentations, objective clinical findings, or laboratory confirmation of active infection. We have undertaken a systematic review of the literature to evaluate several aspects of this practice. Methods Five systematic literature searches were performed using Boolean operators and the PubMed search engine. Results The literature searches did not demonstrate convincing evidence of 1) chronic anaplasmosis infection, 2) treatment responsive symptomatic chronic babesiosis in immunocompetent persons in the absence of fever, laboratory abnormalities and detectable parasitemia, 3) either geographically widespread or treatment responsive symptomatic chronic infection with Babesia duncani in the absence of fever, laboratory abnormalities and detectable parasitemia, 4) tick-borne transmission of Bartonella species, or 5) simultaneous Lyme disease and Bartonella infection. Conclusions The medical literature does not support the diagnosis of chronic, atypical tick-borne coinfections in patients with chronic, nonspecific illnesses.

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Human Babesiosis: Pathogens, Prevalence, Diagnosis, and Treatment

Ord

Lobo

2015

Curr Clin Micro Rpt

110

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Human babesiosis is a zoonotic disease caused by protozoan parasites of the Babesia genus, primarily in the Northeastern and Midwest United States due to B. microti, and Western Europe due to B. divergens. Parasites are transmitted by the bite of the ixodid tick when the vector takes a blood meal from the vertebrate host, and the economic importance of bovine babesiosis is well understood. The pathology of human disease is a direct result of the parasite’s ability to invade host’s red blood cells. The current understanding of human babesiosis epidemiology is that many infections remain asymptomatic, especially in younger or immune competent individuals, and the burden of severe pathology resides within older or immunocompromised individuals. However, transfusion-transmitted babesiosis is an emerging threat to public health as asymptomatic carriers donate blood and there are as yet no licensed or regulated tests to screen blood products for this pathogen. Reports of tick-borne cases within new geographical regions such as the Pacific Northwest of the US, through Eastern Europe, and into China are also on the rise. Further, new Babesia spp. have been identified globally as agents of severe human babesiosis, suggesting that the epidemiology of this disease is rapidly changing, and it is clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measure.

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Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia

Abstract: Video abstract

Cited by 37 publications

References 13 publications

Is there a Lyme-like disease in Australia? Summary of the findings to date

Is there a Lyme-like disease in Australia? Summary of the findings to date

Chronic Coinfections in Patients Diagnosed with Chronic Lyme Disease: A Systematic Review

Human Babesiosis: Pathogens, Prevalence, Diagnosis, and Treatment

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