Emerging hybrid biomaterials for oxidative stress induced photodynamic therapy

Das, Manita; Solanki, Archana; Ganesh, Ashwini; Thakore, Sonal

doi:10.1016/j.pdpdt.2021.102259

Cited by 6 publications

(4 citation statements)

References 70 publications

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“…[27][28][29][30][31][32][33] Mesoporous silica nanoparticles (MSN) are among the most promising theranostic platforms for cancer imaging and therapy. [34][35][36][37][38][39][40][41][42][43][44] Caged drugs/contrast agents in MSN by chemical functionalization protect their intrinsic properties, promote aqueous solubility, and increase tumoral accumulation. [34][35][36][37][38][39][40][41][42][43] Also, the mesoporous structure and high surface-to-volume ratios of MSNs increase the drug/contrast agent loading and delivery efficiencies.…”

Section: Introductionmentioning

confidence: 99%

“…[34][35][36][37][38][39][40][41][42][43][44] Caged drugs/contrast agents in MSN by chemical functionalization protect their intrinsic properties, promote aqueous solubility, and increase tumoral accumulation. [34][35][36][37][38][39][40][41][42][43] Also, the mesoporous structure and high surface-to-volume ratios of MSNs increase the drug/contrast agent loading and delivery efficiencies. 42,43 Recently, Meng and Nel developed lipid bilayer-coated MSN (silicasomes) for intratumoral delivery of chemotherapeutics such as oxaliplatin, gemcitabine, or paclitaxel to the Kras-derived pancreatic cancer in mice.…”

Section: Introductionmentioning

confidence: 99%

“…[34][35][36][37][38][39][40][41][42][43] Also, the mesoporous structure and high surface-to-volume ratios of MSNs increase the drug/contrast agent loading and delivery efficiencies. 42,43 Recently, Meng and Nel developed lipid bilayer-coated MSN (silicasomes) for intratumoral delivery of chemotherapeutics such as oxaliplatin, gemcitabine, or paclitaxel to the Kras-derived pancreatic cancer in mice. 38,39 Similarly, they studied the antitumor effects of irinotecan-loaded silicasomes in pancreatic and colorectal cancers, utilizing the ability of irinotecan to neutralize the lysosomal acidity.…”

Section: Introductionmentioning

confidence: 99%

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Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Sobhanan,

Ono,

Okamoto

et al. 2024

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Sobhanan,

Ono,

Okamoto

et al. 2024

Chem. Sci.

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“…HS induces endothelial cell injury through oxidative stress, which stimulates reactive oxygen species (ROS) generation, lipid peroxidation and DNA damage ( 6 ). ROS are by-products of oxygen metabolism, including superoxide anions, hydrogen peroxide and hydroxyl radicals ( 7 ). ROS target proteins, polysaccharides, DNA and lipids and increase the rate of cell damage ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells

et al. 2021

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The results of a previous study demonstrated that heat stress (HS) triggered oxidative stress, which in turn induced the apoptosis of epithelial cells. These results uncovered a novel mechanism underlying the activation of NF-κB in primary human umbilical vein endothelial cells. The present study aimed to further investigate the role of NF-κB/IκBα signaling pathways in the inhibition of HS-induced reactive oxygen species (ROS) generation and cytotoxicity in endothelial cells. The results of the present study demonstrated that HS triggered a significant amount of NF-κB and IκBα nuclear translocation without IκBα degradation in a time-dependent manner. Mutant constructs of IκBα phosphorylation sites (Ser32, Ser36) were employed in rat pulmonary microvascular endothelial cells (PMVECs). Cell Counting Kit-8 assays demonstrated that both the small interfering (si)RNA-mediated knockdown of p65 and IκBα mutant constructs significantly decreased cell viability and aggravated ROS accumulation in HS-induced rat PMVECs compared with the control. Additionally, western blot analysis revealed that p65 siRNA attenuated the protein expression of IκBα. However, IκBα mutant constructs failed to attenuate NF-κB activation and nuclear translocation, indicating that IκBα-independent pathways contributed to NF-κB activity and nucleus translocation in a time-dependent manner following HS. Collectively, the results of the present study suggested that the NF-κB/IκBα pathway was essential for resistance to HS-induced ROS production and cytotoxicity in rat PMVECs, and that it could be a potential therapeutic target to reduce the mortality and morbidity of heat stroke.

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Engineered Tissue in Cancer Research: Techniques, Challenges, and Current Status

Tripathi¹,

Shukla²,

Sahoo³

et al. 2023

Biological and Medical Physics, Biomedical Engineering

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Emerging hybrid biomaterials for oxidative stress induced photodynamic therapy

Cited by 6 publications

References 70 publications

Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells

Engineered Tissue in Cancer Research: Techniques, Challenges, and Current Status

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