Emerging health risks and underlying toxicological mechanisms of uranium contamination: Lessons from the past two decades

Ma, Minghao; Wang, Ruixia; Xu, Lining; Xu, Ming; Liu, Sijin

doi:10.1016/j.envint.2020.106107

Cited by 162 publications

(44 citation statements)

References 206 publications

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“…While studies using targeted [ 25 , 26 ] and non-targeted [ 27 ] analyses have looked at the effects of high- and low-dose chronic exposure to uranium [ 12 , 28 , 29 ] to assess health risks [ 30 ], the effects of acute low-dose exposure to uranium are still poorly described, even though they are a part of the occupational exposure faced by nuclear workers. To fill this gap, identifying biological signatures that could be used to diagnose the sub-toxic effects of low-dose internal exposure would be relevant to improving the radiation protection and medical monitoring of nuclear workers.…”

Section: Discussionmentioning

confidence: 99%

Early Metabolomic Markers of Acute Low-Dose Exposure to Uranium in Rats

et al. 2022

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Changes in metabolomics over time were studied in rats to identify early biomarkers and highlight the main metabolic pathways that are significantly altered in the period immediately following acute low-dose uranium exposure. A dose response relationship study was established from urine and plasma samples collected periodically over 9 months after the exposure of young adult male rats to uranyl nitrate. LC-MS and biostatistical analysis were used to identify early discriminant metabolites. As expected, low doses of uranium lead to time-based non-toxic biological effects, which can be used to identify early and delayed markers of exposure in both urine and plasma samples. A combination of surrogate markers for uranium exposure was validated from the most discriminant early markers for making effective predictions. N-methyl-nicotinamide, kynurenic acid, serotonin, tryptophan, tryptamine, and indole acetic acid associated with the nicotinate–nicotinamide and tryptophan pathway seem to be one of the main biological targets, as shown previously for chronic contaminations and completed, among others, by betaine metabolism. This study can be considered as a proof of concept for the relevance of metabolomics in the field of low-dose internal contamination by uranium, for the development of predictive diagnostic tests usable for radiotoxicological monitoring.

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Section: Discussionmentioning

confidence: 99%

Early Metabolomic Markers of Acute Low-Dose Exposure to Uranium in Rats

et al. 2022

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“…) and their coordination complexes, which are highly mobile in water and can easily accumulate in living organisms, thus posing a great health risk. 15,16 Therefore, it is of great signicance to develop ratiometric uorescent sensors using which we can identify target analytes through sensitive color changes to achieve real-time detection of UO 2…”

Section: +mentioning

confidence: 99%

An inner-filter-effect based ratiometric fluorescent sensor for the detection of uranyl ions in real samples

et al. 2022

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“…The cumulative effects of excessive uranium levels in the environment endanger human beings and aquatic life, 1 accordingly, uranium monitoring and assessment in real samples has become a growing concern. Natural and anthropogenic uranium contamination can induce severe toxicological and radiological risks; 2 as a result, rapid and sensitive detection of uranium and uranium-bearing compounds is highly demanded for many civilian and military applications.…”

Section: Introductionmentioning

confidence: 99%