Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

Yu, Li; Liu, Shengmao; Jia, Shengnan; Feng, Xiang

doi:10.1016/j.biopha.2023.115049

Cited by 8 publications

(2 citation statements)

References 170 publications

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“…In fact, when mesenchymal stem cells are employed as the vehicles for drug delivery paradigms along with the NPs, these exhibit lower toxicities but sometimes their inefficient accumulation in tumors can be seen because of their clearance by the reticuloendothelial organ systems. To overcome these limitations and problems, internalization or conjugation of therapeutic payload-loaded nanoparticles can be rendered more efficient by encapsulating these in mesenchymal stem cells [ 142 , 143 ].…”

Section: Safety and Toxicity Implications Of Mesenchymal Stem Cell-ba...mentioning

confidence: 99%

Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics

Baig,

Ahmad,

Pathan

et al. 2024

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In the recent past, the formulation and development of nanocarriers has been elaborated into the broader fields and opened various avenues in their preclinical and clinical applications. In particular, the cellular membrane-based nanoformulations have been formulated to surpass and surmount the limitations and restrictions associated with naïve or free forms of therapeutic compounds and circumvent various physicochemical and immunological barriers including but not limited to systemic barriers, microenvironmental roadblocks, and other cellular or subcellular hinderances—which are quite heterogeneous throughout the diseases and patient cohorts. These limitations in drug delivery have been overcome through mesenchymal cells membrane-based precision therapeutics, where these interventions have led to the significant enhancements in therapeutic efficacies. However, the formulation and development of nanocarriers still focuses on optimization of drug delivery paradigms with a one-size-fits-all resolutions. As mesenchymal stem cell membrane-based nanocarriers have been engineered in highly diversified fashions, these are being optimized for delivering the drug payloads in more and better personalized modes, entering the arena of precision as well as personalized nanomedicine. In this Review, we have included some of the advanced nanocarriers which have been designed and been utilized in both the non-personalized as well as precision applicability which can be employed for the improvements in precision nanotherapeutics. In the present report, authors have focused on various other aspects of the advancements in stem cells membrane-based nanoparticle conceptions which can surmount several roadblocks and barriers in drug delivery and nanomedicine. It has been suggested that well-informed designing of these nanocarriers will lead to appreciable improvements in the therapeutic efficacy in therapeutic payload delivery applications. These approaches will also enable the tailored and customized designs of MSC-based nanocarriers for personalized therapeutic applications, and finally amending the patient outcomes.

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Section: Safety and Toxicity Implications Of Mesenchymal Stem Cell-ba...mentioning

confidence: 99%

Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics

Baig,

Ahmad,

Pathan

et al. 2024

JoX

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“…Medical professionals are generally in charge of administering drugs, as opposed to writing prescriptions [ 17 ]. Drug delivery systems provide properties such as targeted distribution and the controlled release of therapeutic drugs [ 18 ]. Drug delivery systems, such as nanocarriers, are typically composed of lipids or polymers as well as associated therapies and can improve many of the pharmacologic properties of free medicines [ 19 ].…”

Section: Oral Drug Deliverymentioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

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Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

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