Emerging erythropoiesis-stimulating agents

Foley, Robert N.

doi:10.1038/nrneph.2010.19

Cited by 12 publications

(7 citation statements)

References 61 publications

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“…This hydroxylase inhibition increases HIF-1α stability and as such impairs the binding of von Hippel-Lindau protein (pVHL) to HIF-1α, resulting in steady accumulation of HIF complexes within the cell nucleus [11]. Hydroxylase inactivity allows HIF-1α to become transcriptionally active for the up-regulation of a large number of hypoxia-sensitive genes [12]. HIF-1α binds to the core DNA sequence of 5'-[AG]CGTG-3' at the hypoxia response element of target gene promoters.…”

Section: Introductionmentioning

confidence: 99%

The Effects of CoCl2 on HIF-1α Protein under Experimental Conditions of Autoprogressive Hypoxia Using Mouse Models

Zhang

Wang

Meister

et al. 2014

IJMS

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It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia. Balb/c mice were randomly divided into groups of chemical pretreatment and normal saline (NS), respectively injected with CoCl2 and NS 3 h before exposure to hypoxia for 0 run (H0), 1 run (H1), and 4 runs (H4). Western Blot, electrophoretic mobility shift assay (EMSA), extracellular recordings population spikes in area cornus ammonis I (CA 1) of mouse hippocampal slices and real-time were used in this study. Our results demonstrated that the tolerance of mice to hypoxia, the changes of HIF-1α protein level and HIF-1 DNA binding activity in mice hippocampus, the mRNA level of erythropoietin (EPO) and vascular endothelial growth factor (VEGF), and the disappearance time of population spikes of hippocampal slices were substantially different between the control group and the CoCl2 group. Over-induction of HIF-1α by pretreatment with CoCl2 before hypoxia did not increase the hypoxia tolerance.

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Section: Introductionmentioning

confidence: 99%

The Effects of CoCl2 on HIF-1α Protein under Experimental Conditions of Autoprogressive Hypoxia Using Mouse Models

Zhang

Wang

Meister

et al. 2014

IJMS

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“…BPGM can decrease the oxygen affinity of hemoglobin in red blood cells, thus helping to compensate for tissue oxygen insufficiency [ 26 ]. Meanwhile, XK (X-Linked Kx Blood Group) and HEMGN (Hemogen) are positively associated with erythrocyte and hematopoietic cell generation, proliferation, and differentiation [ 27 , 28 ], which can be stimulated by hypoxia and inflammation [ 29 – 31 ]. These changes in hypoxia- and inflammation-related genes may indicate hypoxia and inflammation in the transplanted heart and can be used as biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection

Luo

Meng

et al. 2022

Ann Transplant

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Background Cardiac allograft rejection is still a crucial barrier to achieving satisfactory outcomes after surgery. In this study, we propose to find candidate biomarkers from endomyocardial biopsy (EMB) and peripheral blood (PB) samples for efficient diagnosis and treatment of cardiac allograft rejection. Material/Methods Microarray datasets were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) of cardiac allograft rejection patients and control subjects from EMB and PB samples were screened using the online tool GEO2R. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of all samples’ DEGs were performed with the DAVID online tool. Protein–protein interaction (PPI) networks were constructed and visualized using Cytoscape and the top 10 hub genes were selected. Finally, the most highly enriched GO and KEGG pathways of the top 10 hub genes were determined. Results A total of 57 502 genes from EMB samples and 131 624 genes from PB samples were identified. Gene characteristics and enrichment analysis indicated that both EMB and PB samples contained DEGs involved in antigen presentation, immune cells activation, inflammatory process, and cellular injuries. In EMB samples, there were some DEGs related to heart tissue injury and cardiac malfunction. Moreover, DEGs that regulates hypoxia-induced factors and erythrocyte function in response of ischemia and hypoxia stress were present in PB samples but were absent in EMB samples. Conclusions The screened differentially expressed genes (DEGs) from EMB and PB samples of patients with cardiac graft rejection are potential candidate biomarkers of diagnosis and treatment.

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“…However, it has not been proven that intensified Hb >11 g/dL utilizing exogenic EPO translates into a comprehensive benefit for the patients. 5 , 7 New developments promise interesting therapeutic options not only by stimulating erythropoiesis but also by modulating additional mechanisms. In addition to erythropoiesis, EPO has also been reported to have other effects, such as tissue protection and neuroprotection.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis and systematic review evaluating the use of erythropoietin in total hip and knee arthroplasty

Yin

et al. 2018

TCRM

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PurposeThe debate is still ongoing on the effectiveness and safety of erythropoietin (EPO) treatment in orthopedic surgeries. Specifically, previous studies have not compared the dynamic change of hemoglobin (Hb) levels between different transfusion methods. Besides, complications or side effects of this alternative have not been quantitatively analyzed. We conducted a meta-analysis and systemic review to evaluate the efficacy of EPO on Hb levels observed during the whole perioperative period as well as the volume of allogeneic blood transfusion (ABT), the risk of venous thromboembolism, and application frequency of ABT in hip and knee surgery.Materials and methodsPubMed, Embase, Web of Science, and the Cochrane library were systematically searched from inception to November 2017. The data from randomized controlled trials were extracted and the risk of bias assessed using Cochrane’s Collaboration’s tool.ResultsTwenty-five randomized controlled trials involving 4,159 patients were included in this meta-analysis. EPO could reduce exposure to allogeneic blood transfused (odds ratio [OR] =0.42, P=0.001) and reduce the average volume of allogeneic blood transfused (OR = −0.28, P=0.002). When EPO and preoperative autologous blood donation (PABD) were compared, the use of EPO was associated with lower exposure to ABT (OR =0.48, P=0.03), but no significant decrease in the average volume of allogeneic blood transfused (OR = −0.23, P=0.32). The use of EPO was associated with a higher level of Hb with or without use of PABD at all the 4 time points (preoperation, 24–48 hours postoperation, 3–5 days postoperation, discharge of last observation) (P<0.0001), which means EPO could increase the level of Hb significantly during the perioperative period. The results also indicated EPO does not increase the risk of a venous thromboembolism event.ConclusionPreoperative administration of EPO was shown to generally increase Hb levels during the whole perioperative period; however, the extent of the positive effects varies with time points. Additionally, EPO minimizes the need for transfusion significantly in patients undergoing hip or knee surgery without increasing the chance of developing thrombotic complications. Therefore, EPO offers an alternative blood management strategy in total hip arthroplasty and total knee arthroplasty.

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Emerging erythropoiesis-stimulating agents

Cited by 12 publications

References 61 publications

The Effects of CoCl2 on HIF-1α Protein under Experimental Conditions of Autoprogressive Hypoxia Using Mouse Models

The Effects of CoCl2 on HIF-1α Protein under Experimental Conditions of Autoprogressive Hypoxia Using Mouse Models

Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection

A meta-analysis and systematic review evaluating the use of erythropoietin in total hip and knee arthroplasty

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