Emerging Erythromycin Resistance Among Group B Streptococci in Korea

Uh, Young; Jang, In Ho; Hwang, Gyu Yul; Yoon, Kyung Joong; Song, Wonkeun

doi:10.1007/s100960000414

Cited by 28 publications

(39 citation statements)

References 8 publications

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“…Duarte et al (2005) described some resistance to erythromycin (5%) among Ia strains collected between 2000-2001 in Rio de Janeiro. In the present report, susceptibility to other antimicrobial agents is in agreement with other data in the literature (Hsueh et al 2001, Uh et al 2001, Simões et al 2007.…”

Section: Resultssupporting

confidence: 93%

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Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susceptibility profiles of type Ia group B streptococci isolated from humans in Brazil

Corrêa

Oliveira

Pinto

et al. 2009

Mem. Inst. Oswaldo Cruz

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Group B streptococci (GBS) infections occur worldwide. Although serotyping has been used for epidemiologic purposes, this does not accurately characterize enough members of a genetically heterogeneous bacterial population. The aims of this work were to evaluate the genetic diversity of 45 type Ia GBS strains isolated in Brazil byGroup B streptococci (GBS) are responsible for a large variety of human infections and have been recognized over the last few decades as a leading cause of perinatal disease worldwide (Farley 2001, Weisner et al. 2004. GBS are classified in serotypes (Ia, Ib and II-VIII) that occur in combination with different protein antigens (alpha, beta and rib) (Dmitriev et al. 2001). Currently, serotypes Ia, III and V are the most common in many countries (Duarte et al. 2005, Fluegge et al. 2005, Bergseng et al. 2008, Poyart et al. 2008, von Both et al. 2008.Pulsed-field gel electrophoresis (PFGE), used to examine GBS strains, is a powerful technique employed for the classification of microorganisms after digestion of the genomic DNA by restriction enzymes (Benson & Ferrieri 2001, Oliveira et al. 2005, von Both et al. 2008. Using polymerase chain reaction (PCR), Franken et al. (2001) suggested that the scpB and lmb genes (encoding c5a peptidase and laminin binding protein) must exist in GBS strains that infect humans. The hylB gene is frequently detected in these strains (Dore et al. 2003). The bac and bca genes are present in 23% and 100% of type Ia strains, respectively (Maeland et al. 1997(Maeland et al. , 2000.The lack of information on Ia Brazilian strains and the availability of DNA techniques led us to investigate the genetic make-up of type Ia GBS strains isolated in distinct regions of Brazil. Additionally, antimicrobial susceptibility was examined to better characterize these isolates. MATERIALS AND METHODSBacterial strains -Forty-five human type Ia GBS strains derived from clinical specimens were obtained in Florianopolis, Santa Catarina (n = 3), a city located in the Southern Region of Brazil, in São Paulo, São Paulo (SP) (n = 1), and in Rio de Janeiro, Rio de Janeiro (n = 40), in the Southeast Region of the country. The source of one strain was unknown.Isolates were obtained from 1981-2002 from public health laboratories, gynaecological clinics, hospitalsand universities. The clinical sources included urine (n = 16), oropharynx (n = 9), vagina (n = 5), anus (n = 2), lung (n = 2), placenta (n = 1), external ear canal (n = 1) and perineum (n = 1). The sources of eight specimens were unknown. A confirmatory identification of serotypes was carried out again by immunoprecipitation in agarose using sera produced in the research facilities of the authors and HCl antigenic extracts from the streptococci (Benchetrit et al. 1982).PFGE -PFGE was performed as previously described (Oliveira et al. 2005). DNA was digested with the SmaI restriction enzyme (Amersham) and submitted to electrophoresis with a program as follows: switch time of 1-30 sec during 23 h, with a 120º angle, at a temperature of ...

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Section: Resultssupporting

confidence: 93%

“…Variable susceptibilities of GBS to erythromycin and clindamycin (from 4-40%) are described in the literature (Hsueh et al 2001, Uh et al 2001, Díaz et al 2008. Simões et al (2007) did not detect resistance to erythromycin and clindamycin among Ia isolates collected between 2003-2004 in São Paulo.…”

Section: Resultsmentioning

confidence: 99%

Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susceptibility profiles of type Ia group B streptococci isolated from humans in Brazil

Corrêa

Oliveira

Pinto

et al. 2009

Mem. Inst. Oswaldo Cruz

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“…This is in line with previous findings in the Asia, Europe and the United States (Table 1 [ [6][7][8][9][10][11][12][13][14][15][16][17][18][19]). In the study by Morozumi et al [2], 7/32 (21·9%) serotype Ia and 24/88 (27·3%) serotype III GBS isolates showed ML resistance.…”

Section: Association Between Capsular Serotype V and Macrolide Resistsupporting

confidence: 93%

Association between capsular serotype V and macrolide resistance in group B Streptococcus

Sendi

Fröhlicher

2014

Epidemiol. Infect.

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“…One hundred and fifty (150) pregnant women participated in the study over a period of six months (May to December 2010). Their age range was 18-42 years with a mean of 30.25 (±4.65) and the age group in years was categorized as younger (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) and older (≥30) pregnant women, which were 64 (42.7%) and 86 (57.3%) respectively. Table 1 shows parity and gestational age among other parameters as indicated.…”

Section: Resultsmentioning

confidence: 99%

“…Among the subjects that were colonized with GBS, GBS colonization was higher among older women with age ≥30 years (12.79%) against 9.38% in younger (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) women (Table 3). The difference was not statistically significant (X 2 = 0.426; P= 0.514).…”

Section: Resultsmentioning

confidence: 99%

Group B Streptococcus Carriage during Late Pregnancy in Ile-Ife, Nigeria

Onipede¹,

Adefusi²,

Adeyemi³

et al. 2012

Af J Clin Exp Micro

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This study determined the prevalence of Group B Streptococcus (GBS) in late pregnancy and the antimicrobial susceptibility of isolated GBS as well as the impact of GBS infections on pregnancy related clinical outcome with a view of providing an epidemiological baseline data for policy formulation in the teaching hospital. It is an observational and cross-sectional hospital based study. One hundred and fifty pregnant women from 35-40 weeks of gestation were purposively selected and included in the study from May to December 2010. Vaginal swab samples were aseptically collected from the subjects after informed consent. The samples were assayed for presence of GBS. The susceptibility pattern of the isolated GBS to different antibiotics were assessed using disc diffusion and agar dilution techniques based on the Clinical and Laboratory Standards institute(CLSI) standards. The result showed prevalence of 11.3% GBS vaginal colonization which increased with age. There was no significant association between GBS colonization status and age (p >0.05)), gestational age (p >0.05)), gravidity (p >0.05) and obstetric risk factors (p >0.05)). There was no incidence of GBS infection observed. Although, all (17) the GBS isolates were 100% resistance to penicillin, ampicillin, cefoxitin and clindamycin. Resistance to cefotaxime (11.8%), erythromycin (64.7%) and vancomycin 70.6% were observed. Group B Streptococcus colonization in vagina in late pregnancy has been established in the antenatal clinic of the teaching hospital with the attendant risk to the fetus in the population of those affected. There were high and multiple resistance patterns of the GBS isolates to different antibiotics in this study. This calls for a review of the present hospital policy to include the routine screening of GBS during antenatal visits and surveillance.

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Emerging Erythromycin Resistance Among Group B Streptococci in Korea

Cited by 28 publications

References 8 publications

Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susceptibility profiles of type Ia group B streptococci isolated from humans in Brazil

Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susceptibility profiles of type Ia group B streptococci isolated from humans in Brazil

Association between capsular serotype V and macrolide resistance in group B Streptococcus

Group B Streptococcus Carriage during Late Pregnancy in Ile-Ife, Nigeria

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