Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Sharma, Abhishek Kumar; Prasher, Parteek; Aljabali, Alaa A. A.; Mishra, Vijay; Gandhi, Himanshu; Kumar, Sunil; Mutalik, Srinivas; Chellappan, Dinesh Kumar; Tambuwala, Murtaza M.; Dua, Kamal; Kapoor, Deepak

doi:10.1007/s13346-020-00789-2

Cited by 67 publications

(45 citation statements)

References 152 publications

(171 reference statements)

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“…The interactions with functional head groups on polysaccharides enables the incorporation of therapeutic drugs into the main chain through covalent bonds or electrostatic interactions followed by subsequent release of the incorporated drug at target site under a suitable stimuli [31,32]. Similarly, the amphiphilic derivatives of polysaccharides prepared by tethering the hydrophobic moieties to the parent chain possess self-assembly properties in physiological settings and present applications for the delivery of hydrophobic drug molecules such as paclitaxel to the target cells [33][34][35][36].…”

Section: Physicochemical Factorsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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Section: Physicochemical Factorsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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“…Polymersomes just meet this requirement. Polymersome-based therapeutic drug delivery strategies have shown remarkable potential in the therapy of cancer due to their physical and chemical robustness, high drug loading capability, high colloidal stability, significant biocompatibility, and their ability to encapsulate both hydrophilic and hydrophobic molecules [137]. Qin et al…”

Section: Other Drug Delivery Systemsmentioning

confidence: 99%

Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

Sun

Jing

et al. 2021

Sci. China Mater.

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Combination chemotherapy is widely exploited to overcome multidrug resistance (MDR) and enhance the therapeutic effect of anti-tumor agents clinically. The traditional combination regimens applied in clinical practice still suffer from various obstacles, such as inevitable side effects. Fortunately, the application of nanotechnology and the proposal of co-delivery systems make the combination therapy more effective. The occurrence, development, and metastasis of tumors are closely related to the cell cycle. The sensitivity of tumor cells to chemotherapeutic drugs can be improved with the cooperation of cell cycle regulators. In this review, the influence of the cell cycle on tumorigenesis and development is introduced briefly. The current strategies of combining chemotherapeutic drugs and cell cycle regulators through codelivery systems are discussed in detail. We also sketch the possibility of treating tumors mildly via artificially controlling the cell cycle and outline the challenges and perspectives about the improvement of co-delivery systems for cancer therapy.

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“…[ 39 ] Polymersomes, stable polymeric vesicles of amphiphilic block copolymers have more advantages as they enable loading of both hydrophilic and hydrophobic drugs either in their core or shell and potential for surface modification. [ 185 ]…”

Section: Developabilitymentioning

confidence: 99%

Highway to Success—Developing Advanced Polymer Therapeutics

England

Akhtar

2021

Advanced Therapeutics

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Polymer therapeutics are advancing as an important class of drugs. Polymers have already demonstrated their value in extending the half‐life of proteins. They show great potential as delivery systems for improving the therapeutic index of drugs, via biophysical targeting and more recently with more precision targeting. They are also important for intracellular delivery of nucleic acid based drugs. The same frameworks that have been successfully applied to improve the small molecule drug development can be adopted. This approach together with improved pathophysiological disease knowledge and critical developability considerations, imperative given the size and complexity of polymer therapeutics, provides a structured framework that should improve their clinical translation and exploit their functionality and potential. Progress in understanding the right target, gaining the right tissue and cell exposure, ensuring the right safety, selecting the right patient population is discussed. The right commercial considerations are outlined and the need for a multi‐disciplinary approach is emphasized. Crucial developability factors together with scientific and technical advancements to enable pharmaceutical development of a quality robust product are addressed. It is argued that by applying this structured approach to their design and development, polymer therapeutics will continue to grow and develop as important next generation medicines.

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Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Abstract: Emerging era of "somes": polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Cited by 67 publications

References 152 publications

Current-status and applications of polysaccharides in drug delivery systems

Current-status and applications of polysaccharides in drug delivery systems

Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

Highway to Success—Developing Advanced Polymer Therapeutics

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