2022
DOI: 10.1155/2022/5446291
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Emerging Delivery Strategies of Platelet-Rich Plasma with Hydrogels for Wound Healing

Abstract: Platelet-rich plasma (PRP), a platelet-rich plasma concentrate obtained from whole blood, has been widely used to treat wounds due to its high contents of growth factors that can not only play a role in the hemostasis, repair, and anti-infection of wounds but also promote cell proliferation, maturation, and angiogenesis. However, after PRP activation, its clinical effect was limited because of burst and uncontrolled release of growth factors and poor mechanical properties of PRP gels. In recent years, increasi… Show more

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Cited by 6 publications
(4 citation statements)
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“…PRP gel (or fibrin gel) is usually obtained by mixing liquid PRP with exogenous activators such as thrombin, calcium salts, ascorbic acid, batroxobin or collagen [28]. The main limitation of PRP gels is that they do not have sufficient mechanical strength and stability [29].…”
Section: Resultsmentioning
confidence: 99%
“…PRP gel (or fibrin gel) is usually obtained by mixing liquid PRP with exogenous activators such as thrombin, calcium salts, ascorbic acid, batroxobin or collagen [28]. The main limitation of PRP gels is that they do not have sufficient mechanical strength and stability [29].…”
Section: Resultsmentioning
confidence: 99%
“…The facilitation mechanisms of FGF-2 in periodontal regeneration demonstrated in vivo include (1) accelerating and increasing the proliferation of fibroblastic cells originating from the bone marrow and periodontal ligament for the formation of new tissue, (2) increasing angiogenesis, and (3) triggering expression of bone morphogenetic protein-2 (BMP-2) to facilitate osteoblastic differentiation and bone formation [41]. This shows that during the early stages of periodontal tissue regeneration, FGF-2 increases the number of fibroblastic cells, supports angiogenesis, stimulates the growth of chondrocytes and osteoblasts and collagenase expression [41,42]. after periodontal surgery can reduce BoP and PD and significantly increase FGF-2 expression on days 3 and 14.…”
Section: Discussionmentioning
confidence: 99%
“…A full-thickness defect model was used to assess the healing efficiency of the hydrogels. 52,53 In brief, all rats were randomly divided into 9 groups: control, Alfa (available in the market), AGC, AGC–PPP, AGC–PRP, AGC–PPP–PDA (−NIR), AGC–PRP–PDA (−NIR), AGC–PPP–PDA (+NIR), and AGC–PRP–PDA (+NIR). The rats (male, 180 g) were anesthetized using ketamine/xylazine (6 : 4, v/v), and then 10 mm diameter full-thickness skin round wounds were created after shaving on the dorsal area of the rats.…”
Section: Methodsmentioning
confidence: 99%