Emerging concepts towards a translational framework in Alzheimer’s disease

Cozachenco, Danielle; Zimmer, Eduardo R.; Lourenco, Mychael V.

doi:10.1016/j.neubiorev.2023.105246

Cited by 2 publications

(1 citation statement)

References 225 publications

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“…In Costa Rica, Randall Perez has developed a young‐onset dementia service to address diagnostic challenges. Meanwhile, in Brazil, Eduardo Zimmer outlined the potential of blood biomarkers to diagnose Alzheimer's 35,36 in low‐ and middle‐income countries. After that, Des O'Sullivan (England/Ireland) shared his journey living with Lewy body dementia, stressing the importance of early detection 37 …”

Section: Resultsmentioning

confidence: 99%

Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Aguzzoli Peres,

Haas,

Martha

et al. 2024

Alzheimer's & Dementia

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Coping with dementia requires an integrated approach encompassing personal, health, research, and community domains. Here we describe “Walking the Talk for Dementia,” an immersive initiative aimed at empowering people with dementia, enhancing dementia understanding, and inspiring collaborations. This initiative involved 300 participants from 25 nationalities, including people with dementia, care partners, clinicians, policymakers, researchers, and advocates for a 4‐day, 40 km walk through the Camino de Santiago de Compostela, Spain. A 2‐day symposium after the journey provided novel transdisciplinary and horizontal structures, deconstructing traditional hierarchies. The innovation of this initiative lies in its ability to merge a physical experience with knowledge exchange for diversifying individuals' understanding of dementia. It showcases the transformative potential of an immersive, embodied, and multi‐experiential approach to address the complexities of dementia collaboratively. The initiative offers a scalable model to enhance understanding, decrease stigma, and promote more comprehensive and empathetic dementia care and research.

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Section: Resultsmentioning

confidence: 99%

Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Aguzzoli Peres,

Haas,

Martha

et al. 2024

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

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Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

Granzotto,

Vissel,

Sensi

2024

eLife

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The recent, controversial approval of antibody-based treatments for Alzheimer’s disease (AD) is fueling a heated debate on the molecular determinants of this condition. The discussion should also incorporate a critical revision of the limitations of preclinical mouse models in advancing our understanding of AD. We critically discuss the limitations of animal models, stressing the need for careful consideration of how experiments are designed and results interpreted. We identify the shortcomings of AD models to recapitulate the complexity of the human disease. We dissect these issues at the quantitative, qualitative, temporal, and context-dependent levels. We argue that these models are based on the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH) of AD and fail to account for the multifactorial nature of the condition. By shedding light on the constraints of current experimental tools, this review aims to foster the development and implementation of more clinically relevant tools. While we do not rule out a role for preclinical models, we call for alternative approaches to be explored and, most importantly, for a re-evaluation of the ACH.

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Emerging concepts towards a translational framework in Alzheimer’s disease

Cited by 2 publications

References 225 publications

Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

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