Emerging concepts of myosin 18A isoform mechanobiology in organismal and immune system physiology, development, and function
William DeKryger,
Zissis C. Chroneos
Abstract:Alternative and combinatorial splicing of myosin 18A (MYO18A) gene transcripts results in expression of MYO18A protein isoforms and isoform variants with different membrane and subcellular localizations, and functional properties. MYO18A proteins are members of the myosin superfamily consisting of a myosin‐like motor domain, an IQ motif, and a coiled‐coil domain. MYO18A isoforms, however, lack the ability to hydrolyze ATP and do not perform ATP‐dependent motor activity. MYO18A isoforms are distinguished by dif… Show more
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