Emerging Concepts of Endotypes/Phenotypes in Regenerative Medicine for Osteoarthritis

Im, Gun‐Il; Moon, Jae-Yeon

doi:10.1007/s13770-021-00397-2

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…In addition, the selection of proper medication for specific disease time points will help in defining gender-tailored treatments for each patient. Furthermore, it should be considered that OA may be characterized by combined endotype, such as an inflammatory pain endotype that could benefit from a combination of pharmaceuticals addressing both pain and inflammation [ 96 , 97 ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Gender-Related Aspects in Osteoarthritis Development and Progression: A Review

Peshkova

Лычагин

Lipina

et al. 2022

IJMS

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Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically before approaching its definitive treatment, joint arthroplasty. The rapidly growing prevalence of OA highlights the urgent need for a more efficient treatment strategy and boosts research into the mechanisms of OA incidence and progression. As a multifactorial disease, many aspects have been investigated as contributors to OA onset and progression. Differences in gender appear to play a role in the natural history of the disease, since female sex is known to increase the susceptibility to its development. The aim of the present review is to investigate the cues associated with gender by analyzing various hormonal, anatomical, molecular, and biomechanical parameters, as well as their differences between sexes. Our findings reveal the possible implications of gender in OA onset and progression and provide evidence for gaps in the current state of art, thus suggesting future research directions.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Gender-Related Aspects in Osteoarthritis Development and Progression: A Review

Peshkova

Лычагин

Lipina

et al. 2022

IJMS

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“…This would open up a window for regenerative intervention to stop progression of OA ( 7 ). Emerging concepts to assess the different stages and progression of OA are based on the description of clinical phenotypes and molecular endotypes ( 8 , 9 ). Rational for these concepts is a targeted approach of OA treatment tailored to the disease stage.…”

Section: Osteoarthritismentioning

confidence: 99%

Osteoarthritis, adipokines and the translational research potential in small animal patients

Theyse,

Mazur

2024

Front. Vet. Sci.

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Osteoartritis (OA) is a debilitating disease affecting both humans and animals. In the early stages, OA is characterized by damage to the extracellular matrix (ECM) and apoptosis and depletion of chondrocytes. OA progression is characterized by hyaline cartilage loss, chondrophyte and osteophyte formation, thickening of the joint capsule and function loss in the later stages. As the regenerative potential of cartilage is very limited and osteoarthritic changes are irreversible, prevention of OA, modulation of existing osteoarthritic joint inflammation, reducing joint pain and supporting joint function are the only options. Progression of OA and pain may necessitate surgical intervention with joint replacement or arthrodesis as end-stage procedures. In human medicine, the role of adipokines in the development and progression of OA has received increasing interest. At present, the known adipokines include leptin, adiponectin, visfatin, resistin, progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin. Adipokines have been demonstrated to play a pivotal role in joint homeostasis by modulating anabolic and catabolic balance, autophagy, apoptosis and inflammatory responses. In small animals, in terms of dogs and cats, naturally occurring OA has been clearly demonstrated as a clinical problem. Similar to humans, the etiology of OA is multifactorial and has not been fully elucidated. Humans, dogs and cats share many joint related degenerative diseases leading to OA. In this review, joint homeostasis, OA, adipokines and the most common joint diseases in small animals leading to naturally occurring OA and their relation with adipokines are discussed. The purpose of this review is highlighting the translational potential of OA and adipokines research in small animal patients.

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“…Osteoarthritis (OA) is a debilitating joint disease affecting both humans and companion and farm animals [1,2]. Diarthrodial or synovial joints are essential for the articulation between opposing parts of the skeleton.…”

Section: Osteoarthritismentioning

confidence: 99%

“…This would open up a window for regenerative intervention to stop the progression of OA [9]. Emerging concepts to assess the different stages and progression of OA are based on the description of clinical phenotypes and molecular endotypes [1,2]. In the early stages, OA is characterized by damage to the ECM and depletion of chondrocytes [10].…”

Section: Osteoarthritismentioning

confidence: 99%

Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions

Werry,

Mazur,

Theyse

et al. 2023

IJMS

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Osteoarthritis (OA) is one of the most common chronic diseases in human and animal joints. The joints undergo several morphological and histological changes during the development of radiographically visible osteoarthritis. The most discussed changes include synovial inflammation, the massive destruction of articular cartilage and ongoing joint destruction accompanied by massive joint pain in the later stadium. Either the increased apoptosis of chondrocytes or the insufficient apoptosis of inflammatory macrophages and synovial fibroblasts are likely to underly this process. In this review, we discuss the current state of research on the pathogenesis of OA with special regard to the involvement of apoptosis.

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Emerging Concepts of Endotypes/Phenotypes in Regenerative Medicine for Osteoarthritis

Cited by 7 publications

References 20 publications

Gender-Related Aspects in Osteoarthritis Development and Progression: A Review

Gender-Related Aspects in Osteoarthritis Development and Progression: A Review

Osteoarthritis, adipokines and the translational research potential in small animal patients

Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions

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