Emerging biopharmaceuticals from bioactive peptides derived from marine organisms

Abstract

Biologically active natural products are spontaneous medicinal entrants, which encourage synthetic access for enhancing and supporting drug discovery and development. Marine bioactive peptides are considered as a rich source of natural products that may provide long-term health, in addition to many prophylactic and curative medicinal drug treatments. The large literature concerning marine peptides has been collected, which shows high potential of nutraceutical and therapeutic efficacy encompassing wide spectra of bioactivities against a number of infection-causing agents. Their antimicrobial, antimalarial, antitumor, antiviral, and cardioprotective actions have achieved the attention of the pharmaceutical industry toward new design of drug formulations, for treatment and prevention of several infections. However, the mechanism of action of many peptide molecules has been still untapped. So in this regard, this paper reviews several peptide compounds by which they interfere with human pathogenesis. This knowledge is one of the key tools to be understood especially for the biotransformation of biomolecules into targeted medicines. The fact that different diseases have the capability to fight at different sites inside the body can lead to a new wave of increasing the chances to produce targeted medicines.

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

“…Most of these metabolites are biologically active and are produced either through the non-ribosomal polypeptide (NRP) or the hybrid polyketide-NRP biosynthetic pathways. Their structural types are important subsets of natural products possessing medical capacities such as dolastatin 10 which is known as a tubulin polymerization inhibitor, the vancomycin antibiotic, cyclosporine as an immunosuppressant, bleomycin as a chemotherapy drug, and largazole and santacruzamate A as histone deacetylase inhibitors [ 11 , 12 , 13 ]. Therefore, cyanobacteria have been regarded as a powerful source of secondary metabolites with possible technological applications in the pharmaceutical field leading to an increase in interest in these research realms [ 14 ].…”

Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

“…Among marine organisms 58. , 59. , marine sponges have played an important role in anti-HIV natural products discovery 60 .…”

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

“…Furthermore, they can target cancer cells and stimulate immunity. Recent articles by Liu et al [30] and Anjun et al [31] provide reviews of many new AMPs and their possible uses for pharmaceutical purposes.…”

“…Genomic approaches have diversified the number of marine peptides that exhibit pharmacological activity [55,56,57,58]. An exhaustive list of marine peptides and polypeptides and their pharmacological activities have been provided in some reviews [31,34,37,38,59,60,61,62]. We have included the names of some of the marine peptides derived from marine resources that have been published from 2009 to 2016 in Table 1.…”