Emerging Association Between Parathyroid Hormone and Anemia in Hemodialysis Patients

Tanaka, Motoko; Komaba, Hirotaka; Fukagawa, Masafumi

doi:10.1111/1744-9987.12685

Cited by 58 publications

(53 citation statements)

References 40 publications

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“…A decrease in the glomerular filtration rate results in decreased renal excretion of phosphate, thereby activating phosphaturic hormone excretion, such as fibroblast growth factor 23 or parathyroid hormone, such that there is an increase in the reabsorption of phosphate through the sodium-phosphate cotransporter in remnant nephrons [32]. The parathyroid hormone reduces RBC formation by inhibiting their maturation in the bone marrow [33]. The abating effect on RBC might be a possible mechanism of hyperparathyroidism in RLS.…”

Section: Discussionmentioning

confidence: 99%

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

Hou

Fan

Huang

et al. 2020

JCM

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Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SPECT was a biomarker for RLS but the correlation between the physiologic parameter was lacking. Methods: Overall, 32 patients were enrolled in the study and divided into the following 3 groups: (1) control (n = 13), (2) ESRD without RLS (n = 8) and (3) ESRD with RLS (n = 11). All patients had a clinical diagnosis of RLS and received Tc-99m TRODAT-1 SPECT. A subgroup analysis was performed to compare differences between the control and ESRD with RLS groups. Tc-99m TRODAT-1 SPECT was performed and activities in the striatum and occipital areas were measured using manually delineated regions of interest (ROIs) by an experienced nuclear medicine radiologist who was blinded to clinical data. Results: The total ratio of Tc-99m TRODAT SPECT was lower in the ESRD with RLS group (p = 0.046). The uptake ratio of TRODAT negatively correlated with serum parathyroid hormone (r = −0.577, p = 0.015) and ferritin (r = −0.464, p = 0.039) concentrations. However, the uptake positively correlated with the hemoglobin concentration (r = 0.531, p = 0.011). The sensitivity and specificity of the total TRODAT ratio for predicting RLS in the overall population were 95.0% and 67.7%, respectively, at a cutoff value of 0.980 (area under the curve of receiver operating characteristic curve was 0.767, p = 0.024). Conclusion: In patients with ESRD and RLS, Tc-99m TRODAT might be a potential biomarker. Dysregulated hemoglobin, serum parathyroid hormone and serum ferritin concentrations might influence the uptake of the TRODAT ratio.

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Section: Discussionmentioning

confidence: 99%

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

Hou

Fan

Huang

et al. 2020

JCM

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“…High FGF23 levels cause chronic inflammation, which can also contribute to anemia and EPO resistance in these patients. 38 Accumulated evidence supports the causal role of PTH in anemia in patients with CKD and provides an additional justification to control the secretion of this hormone in these patients. 38,39 Thus, HPTS control should be considered a strategy for EPO resistance reversal.…”

Section: Secondary Hyperparathyroidismmentioning

confidence: 92%

<p>Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives</p>

Santos¹,

Dias²,

Lima³

et al. 2020

IJNRD

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Anemia is a frequent complication of chronic kidney disease, and its primary cause is erythropoietin deficiency. After diagnosis, treatment begins with administration of an erythropoiesis-stimulating agent (ESA). However, some patients present with resistance to ESA, which needs to be reversed, as it can increase the risk of death in patients with kidney disease. Therefore, we provide a discussion of the current literature regarding the factors that can modify the response to this class of drugs and the strategies that can be considered to optimize the benefits of treating anemia.

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“…In hyperparathyroidism, anemia is relatively rare only in severe cases of the disease, when there are signs of bone resorption, the blood levels of Ca 2+ and parathyroid hormone, alkaline phosphatase activity are very high [28]. Parathyroid hormone inhibits the proliferation of erythroid germ cells by suppressing erythropoietin receptors on erythroid progenitor cells in the bone marrow.…”

Section: Disorders Of the Parathyroid Glandsmentioning

confidence: 99%

Untitled

Piriatinska

Vdovichenco

Бакурідзе-Маніна

et al. 2020

PEP

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Anemia is a public health problem in almost all countries in the world, negatively affects human health,affects all sectors of the population and creates serious negative socio-economic consequences. The fact of anemiais the basis for stating a pathological condition that requires a nosological diagnosis with the identificationof the causes of anemia. The article presents a review of modern literature, covering the impact of endocrinepathology on the development of various types of anemia in humans. The importance of biologically activesubstances in normal erythropoiesis is described, the role of erythropoietin and the action of hormones of theendocrine glands on its formation are considered. Endocrine pathologies such as hypo- and hyperthyroidism,hypo- and hyperparathyroidism, diabetes mellitus, insufficiency of the pituitary, hypothalamus, sex glands,adrenal glands and features of the development of anemic conditions are discussed. An analysis of the literatureshowed that an increase or decrease in the function of individual endocrine glands leads to a disruption in theformation of erythropoietin, impaired absorption of iron, folic acid and vitamin B12 a nd, a s a r esult, i neffectiveerythropoiesis. Anemia negatively affects the course of the underlying disease, significantly worsening itsprognosis, and its treatment is more often effective only in conjunction with the adjustment of hormonal status.Despite significant progress in the study of the pathogenesis of anemia, the emergence of new scientific data onthe issues and mechanisms of regulation of erythropoiesis, classification options for anemia are still being discussed,the criteria for diagnosing a number of anemias and its combination with chronic diseases of endocrineand non-endocrine nature are being reviewed.

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Emerging Association Between Parathyroid Hormone and Anemia in Hemodialysis Patients

Cited by 58 publications

References 40 publications

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

<p>Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives</p>

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