Emerging Areas in Copper‐Mediated Trifluoromethylations OF ARYL DERIVATIVES: Catalytic and Oxidative Cross‐Coupling Processes

A mechanistic investigation of the photoinduced, copper-mediated cross-coupling of an aryl thiol with an aryl halide

“…The utility of cross-coupling chemistry has continued to expand at a rapid rate as novel or underexplored reaction pathways are exploited to achieve important new families of bond constructions. 1 We have recently reported that, in the presence of light and a simple copper catalyst, coupling reactions of a variety of nucleophiles (nitrogen, sulfur, oxygen, and carbon) with aryl or alkyl electrophiles can be accomplished under mild conditions (−40 to 30 °C; eqn (1)). 2–4 …”

Copper-(Photo)Catalyzed Radical Reactions with Organic Halides

“…Other organic halides such as alkenyl, allenyl and alkynyl halides can also be utilized, yielding the corresponding alkenylated, allenylated and alkynylated heteronucleophiles, respectively. 15 After developing a general and efficient synthesis of ynamides by a coppercatalyzed cross-coupling of nitrogen nucleophiles and gem-This article is protected by copyright. All rights reserved.…”

Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)

“…Among the different developed strategies to ravel synthetic issues, the use of inexpensive and readily available copper-based fluorinated reagents appeared over the years as a powerful tool in various transformations for the introduction of fluorinated moieties. Such strategy has already demonstrated a significant synthetic value for the trifluoromethylation of various compounds [16][17][18][19][20][21][22][23][24][25][26][27]. In contrast, available reagents for the incorporation of a CF 2 R (R = H, alkyl, R F , FG; FG = functional group) moiety remain restricted, despite the potential of these functionalized fluorinated moieties.…”