Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury

O‘Donnell, John C.; Swanson, Randel L.; Wofford, Kathryn L.; Grovola, Michael R.; Purvis, Erin M.; Petrov, Dmitriy; Cullen, D. Kacy

doi:10.1007/978-3-030-95884-8_13

Cited by 2 publications

(2 citation statements)

References 325 publications

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“…Therefore, with the humane treatment of research animals as a top priority, chronic studies have been limited to mild TBI [55,75,106], and studies of swine in extended coma have not exceeded 8 h [37,[42][43][44]. Only by providing these subjects with the same neurocritical care afforded to a human patient can we ethically and practically extend beyond the acute period for translational study of rehabilitation [107]. Therefore, in addition to developing new diagnostics, therapeutics, and improving prognostic capabilities in the neurocritical care space, we can now do the same for the recovery/rehabilitation phase following moderate-to-severe TBI with coma.…”

Section: Future Directions For Translational Sah and Tbi Studiesmentioning

confidence: 99%

Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research

et al. 2023

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Neurocritical care significantly impacts outcomes after moderate-to-severe acquired brain injury, but it is rarely applied in preclinical studies. We created a comprehensive neurointensive care unit (neuroICU) for use in swine to account for the influence of neurocritical care, collect clinically relevant monitoring data, and create a paradigm that is capable of validating therapeutics/diagnostics in the unique neurocritical care space. Our multidisciplinary team of neuroscientists, neurointensivists, and veterinarians adapted/optimized the clinical neuroICU (e.g., multimodal neuromonitoring) and critical care pathways (e.g., managing cerebral perfusion pressure with sedation, ventilation, and hypertonic saline) for use in swine. Moreover, this neurocritical care paradigm enabled the first demonstration of an extended preclinical study period for moderate-to-severe traumatic brain injury with coma beyond 8 h. There are many similarities with humans that make swine an ideal model species for brain injury studies, including a large brain mass, gyrencephalic cortex, high white matter volume, and topography of basal cisterns, amongst other critical factors. Here we describe the neurocritical care techniques we developed and the medical management of swine following subarachnoid hemorrhage and traumatic brain injury with coma. Incorporating neurocritical care in swine studies will reduce the translational gap for therapeutics and diagnostics specifically tailored for moderate-to-severe acquired brain injury.

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Section: Future Directions For Translational Sah and Tbi Studiesmentioning

confidence: 99%

Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research

et al. 2023

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“…Neurotrauma and neurodegenerative diseases that impact these essential astrocytic functions can be devastating to the brain and the organism as a whole (for reviews, see [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]). Their central role in facilitating both healthy brain function and the mechanisms of neurotrauma and neurodegenerative disease, combined with their resilience relative to neighboring neurons, make astrocytes a very attractive therapeutic target [ 9 , 10 , 11 ]. Translating such therapies will require investigations in a large animal model like pigs to investigate the mechanisms and manifestations of human injuries more closely.…”

Section: Introductionmentioning

confidence: 99%

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Purvis,

Fedorczak,

Prah

et al. 2023

Biomedicines

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Astrocytes are essential to virtually all brain processes, from ion homeostasis to neurovascular coupling to metabolism, and even play an active role in signaling and plasticity. Astrocytic dysfunction can be devastating to neighboring neurons made inherently vulnerable by their polarized, excitable membranes. Therefore, correcting astrocyte dysfunction is an attractive therapeutic target to enhance neuroprotection and recovery following acquired brain injury. However, the translation of such therapeutic strategies is hindered by a knowledge base dependent almost entirely on rodent data. To facilitate additional astrocytic research in the translatable pig model, we present a review of astrocyte findings from pig studies of health and disease. We hope that this review can serve as a road map for intrepid pig researchers interested in studying astrocyte biology.

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Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury

Cited by 2 publications

References 325 publications

Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research

Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

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