Emerging Applications of Bacteriocins as Antimicrobials, Anticancer Drugs, and Modulators of The Gastrointestinal Microbiota

Cesa-Luna, Catherine; Alatorre-Cruz, Julia María; Carreño-López, Ricardo; Quintero-Hernández, Verónica; Baez, Antonino

doi:10.33073/pjm-2021-020

Cited by 26 publications

(16 citation statements)

References 150 publications

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Section: Introductionmentioning

confidence: 99%

“…8 Thus, bacteriocins appear to be critical molecular factors influencing the proper microbiome composition of the skin, mucous membranes, and gastrointestinal and urogenital tracts. 5,9 Bacteriocins are peptides or proteins with various sizes, structures, mechanisms of action, and organization of genes. For example, bacteriocins produced by staphylococci -widespread residents and opportunistic pathogens of the skin and mucous membranes of humans and many animals -comprise four groups: 1) lantibiotics (small single-chain posttranslationally modified peptides, such as epidermin, gallidermin, or BacCH91), 2) unmodified single-chain peptides (such as aureocin A53, epidermicin NI01, and BacSp222), 3) unmodified multi-chain peptides (such as staphylococcin C55 and aureocin A70), and 4) bacteriolytic enzymes (such as lysostaphins LSs and LSp222 as well as endopeptidase ALE-1).…”

Section: Introductionmentioning

confidence: 99%

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Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells 

Śmiałek¹,

Bzowska²,

Hinz³

et al. 2022

JIR

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Purpose The zoonotic opportunistic pathogen Staphylococcus pseudintermedius 222 produces BacSp222 – an atypical peptide exhibiting the features of a bacteriocin, a virulence factor, and a molecule modulating the host inflammatory reaction. The peptide is secreted in an unmodified form and, additionally, two forms modified posttranslationally by succinylation. This study is a comprehensive report focusing on the proinflammatory properties of such molecules. Methods The study was performed on mouse monocyte/macrophage-like and endothelial cell lines as well as human neutrophils. The following peptides were studied: BacSp222, its succinylated forms, the form deprived of formylated methionine, and a reference bacteriocin – nisin. The measurements of the nitric oxide (NO) level, induced NO synthase (iNOS) expression, the profile of secreted cytokines, NF-kappa-B activation, reactive oxygen species (ROS) biosynthesis, and the formation of extracellular traps were conducted to evaluate the proinflammatory activity of the studied peptides. Results BacSp222 and its succinylated forms effectively induced NO production and iNOS expression when combined with IFN-gamma in macrophage-like cells. All natural BacSp222 forms used alone or with IFN-gamma stimulated the production of TNF-alpha, MCP-1, and IL-1-alpha, while the co-stimulation with IFN-gamma increased IL-10 and IL-27. Upregulated TNF-alpha secretion observed after BacSp222 exposition resulted from increased expression but not from membrane TNF-alpha proteolysis. In neutrophils, all forms of bacteriocin upregulated IL-8, but did not induce ROS production or NETs formation. In all experiments, the activities of deformylated bacteriocin were lower or unequivocal in comparison to other forms of the peptide. Conclusion All naturally secreted forms of BacSp222 exhibit proinflammatory activity against monocyte-macrophage cells and neutrophils, confirming that the biological role of BacSp222 goes beyond bactericidal and cytotoxic effects. The atypical posttranslational modification (succinylation) does not diminish its immunomodulatory activity in contrast to the lower antibacterial potential or cytotoxicity of such modified form established in previous studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells 

Śmiałek¹,

Bzowska²,

Hinz³

et al. 2022

JIR

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“…Huang et al (2021) highlights the potential of bacteriocins as novel therapeutic treatments in microbe infection, cancer, and immune system in human body. Cesa-Luna et al (2021) also reveal the advance usage of bacteriocin as biocontrol agent in medical and agricultural field. Along with these, they discussed about their mode of action and role of bacteriocins to modulate the signaling in host-associated microbial populations.…”

Section: Bacterial Therapy Of Cancer-a Newer Approachmentioning

confidence: 94%

Role of Probiotics on Skin Health

Chatterjee¹,

Das²

2022

Modern Approaches in Chemical and Biological Sciences

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Like the internal digestive system, the largest organ of our body, the skin, maintains a healthy balance with the natural inhabitants of it. Skin act as a host for several microorganisms (about one million per square centimetre) including different types of bacteria, fungi, and viruses. This microbiome takes active role in the fighting with infection, providing protection against environmental damage, regulation of pH and in keeping the skin hydrated and healthy. Probiotics are live and healthy microorganisms that can be consumed directly to restore the pH levels and the balance in the guts. They act like good bacteria and are important to keep away the “bad” bacteria from multiplying in different organ of human body. They can also be applied on the skin to restore the skin's ecosystem, pH and immunity. Again, long term exposure to solar radiation may induce UV damaged skin cancer. The utilization of probiotic bacteria in skin cancer research may help in development of new skin cancer prevention and treatment options.

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“…In comparison to antibiotics, their mode of action rarely induces resistance. Further, different bacteriocins exist with either narrow or broad-spectrum killing capacities, making them attractive for biotechnological use (reviewed in [ 190 ]). More research on their mode of action as well as the spectrum of activity is needed in order to use them efficiently as microbiota-modulating drugs.…”

Section: Microbiota-targeted Interventions Are Promising Tools To Imp...mentioning

confidence: 99%

Intestinal microbiota research from a global perspective

Wallenborn

Vonaesch

2022

Gastroenterology Report

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The intestinal microbiota plays a crucial role in health and changes in its composition are linked with major global human diseases. Fully understanding what shapes the human intestinal microbiota composition and knowing ways of modulating the composition are critical for promotion of life-course health, combating diseases, and reducing global health disparities. We aim to provide a foundation for understanding what shapes the human intestinal microbiota on an individual and global scale, and how interventions could utilize this information to promote life-course health and reduce global health disparities. We briefly review experiences within the first 1,000 days of life and how long-term exposures to environmental elements or geographic specific cultures have lasting impacts on the intestinal microbiota. We also discuss major public health threats linked to the intestinal microbiota, including antimicrobial resistance and disappearing microbial diversity due to globalization. In order to promote global health, we argue that the interplay of the larger ecosystem with intestinal microbiota research should be utilized for future research and urge for global efforts to conserve microbial diversity.

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Emerging Applications of Bacteriocins as Antimicrobials, Anticancer Drugs, and Modulators of The Gastrointestinal Microbiota

Cited by 26 publications

References 150 publications

Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells

Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells

Role of Probiotics on Skin Health

Intestinal microbiota research from a global perspective

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