Emerging and re-emerging viral diseases, predisposing risk factors, and implications of international travel: a call for action for increasing vigilance and imposing restrictions under the current threats of recently emerging multiple Omicron subvariants

Kaiwan, Oroshay; Sethi, Yashendra; Khehra, Nimrat; Padda, Inderbir; Chopra, Hitesh; Chandran, Deepak; Dhama, Kuldeep; Chakraborty, Chiranjib; Islam, Md. Aminul; Kaka, Nirja

doi:10.1097/js9.0000000000000176

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…The spread, and burden, of such diseases have become even greater and more common in the past few decades as we began to live in a highly globalized and interconnected world. Technological advances and economical changes led to increased migration between different countries due to cheaper and faster travels; population growth led to increased contact between people, while climate changes allowed for the existence of pathogens and vectors in places where they were not common before [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Targeting Proteases for Antiviral Development

Borges,

Ferreira,

Silva

2024

Viruses

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Viral proteases are an important target for drug development, since they can modulate vital pathways in viral replication, maturation, assembly and cell entry. With the (re)appearance of several new viruses responsible for causing diseases in humans, like the West Nile virus (WNV) and the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding the mechanisms behind blocking viral protease’s function is pivotal for the development of new antiviral drugs and therapeutical strategies. Apart from directly inhibiting the target protease, usually by targeting its active site, several new pathways have been explored to impair its activity, such as inducing protein aggregation, targeting allosteric sites or by inducing protein degradation by cellular proteasomes, which can be extremely valuable when considering the emerging drug-resistant strains. In this review, we aim to discuss the recent advances on a broad range of viral proteases inhibitors, therapies and molecular approaches for protein inactivation or degradation, giving an insight on different possible strategies against this important class of antiviral target.

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Section: Introductionmentioning

confidence: 99%