Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances

Chouhan, Dimple; Dey, Namit; Bhardwaj, Nandana; Mandal, Biman B.

doi:10.1016/j.biomaterials.2019.119267

Cited by 374 publications

(252 citation statements)

References 137 publications

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“…However, at present, in situ bioprinting is only achievable for small wounds (<3 × 3 cm). For wounds with larger surface areas, cell proliferation, tissue maturation and vasculature formation within the bioprinted skin construct will be necessary to maintain the graft viability in vivo [ 137 ]. This can potentially be achieved by first printing the skin construct in vitro, where a construct of a specific size, geometry and cellular composition is fabricated based on a 3D scan of the graft area on the patient before transplanting onto the wound.…”

Section: Three-dimensional Bioprinting Approaches To Aid Wound Repmentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.

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Section: Three-dimensional Bioprinting Approaches To Aid Wound Repmentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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“…Chronic and complicated skin wounds generally undergo hypoxia, which results in delayed healing process, increased amount of wound necrotic tissue and impaired ability to combat microbial contamination [39,40]. Besides the requirements of wound microenvironment (nutrition, oxygenation, vascularization), other external factors must be considered during the healing of chronic wounds, including moisture, temperature and pressure [41].…”

Section: Wound Healing Processmentioning

confidence: 99%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

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“…The most common types are polymeric micro and nanospheres, lipid nanoparticles, nanofibrous structures, coacervate, hydrogels, and scaffolds (Kakkar et al, 2017;Mansurov et al, 2017;Wang et al, 2017;Chen et al, 2018). Various polymer compositions of these delivery systems have demonstrated their potential in future therapeutic treatments, especially for tissue repair and regeneration (Saghazadeh et al, 2018;Chouhan et al, 2019). In this regard, the effects of various cytokines and growth factors on wound healing using various biomaterials have been studied.…”

Section: Introductionmentioning

confidence: 99%

Sequential Delivery of Cryogel Released Growth Factors and Cytokines Accelerates Wound Healing and Improves Tissue Regeneration

Jimi

Jaguparov

Nurkesh

et al. 2020

Front. Bioeng. Biotechnol.

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Growth factors and cytokines that are secreted by cells play a crucial role in the complex physiological reaction to tissue injury. The ability to spatially and temporally control their actions to maximize regenerative benefits and minimize side effects will help accelerate wound healing and improve tissue regeneration. In this study, the sequential targeted delivery of growth factor/cytokine combinations with regulatory functions on inflammation and tissue regeneration was examined using an internal splint wound healing model. Four examined growth factors and cytokines were effectively incorporated into a novel chitosan-based cryogel, which offered a controlled and sustained release of all factors while maintaining their biological activities. The cryogels incorporated with inflammation modulatory factors (IL-10 and TGF-β) and with wound healing factors (VEGF and FGF) were placed on the wound surface on day 0 and day 3, respectively, after wound initiation. Although wound area gradually decreased in all groups over time, the area in the cryogel group with growth factor/cytokine combinations was significantly reduced starting on day 7 and reached about 10% on day 10, as compared to 60-65% in the control groups. Sequential delivery of inflammation modulatory and wound healing factors enhanced granulation tissue formation, as well as functional neovascularization, leading to regenerative epithelialization. Collectively, the chitosan-based cryogel can serve as a controlled release system for sequential delivery of several growth factors and cytokines to accelerate tissue repair and regeneration.

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Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances

Cited by 374 publications

References 137 publications

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

The importance of oxygen release in diabetic foot ulcer wounds

Sequential Delivery of Cryogel Released Growth Factors and Cytokines Accelerates Wound Healing and Improves Tissue Regeneration

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