Emerging and critical issues in the pathogenesis of lupus

Gatto, Mariele; Zen, Margherita; Ghirardello, Anna; Bettio, Silvano; Bassi, Nicola; Iaccarino, Leonardo; Punzi, Leonardo; Doria, Andrea

doi:10.1016/j.autrev.2012.09.003

Cited by 116 publications

(94 citation statements)

References 160 publications

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…33,34 Beside autoreactive B lymphocytes and autoantibody-secreting plasma cells, T reg cells, NKTcells, mesenchymal stem cells, DCs and autoreactive T cells are also involved in the immunopathogenesis of SLE. [34][35][36] Mice susceptible to autoimmune diseases, including lupus, have abnormal germinal center reactions, which seem essential in triggering autoimmune signals. 37 Spontaneously generated splenic germinal centers were associated with autoantibody production and atypical distribution of B220 þ PNA þ (peanut agglutinin) GL-7 þ (Ly77 or B-/T-cell activation marker) B cells and M1 þ (Murine 1) follicular DCs.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

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Galectin-3 in autoimmunity and autoimmune diseases

Oliveira

Gatto

Bassi

et al. 2015

Exp Biol Med (Maywood)

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142

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Galectin-3 (gal-3) is a b-galactoside-binding lectin, which regulates cell-cell and extracellular interactions during self/ non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis. It plays a significant role in cellular and tissue pathophysiology by organizing niches that drive inflammation and immune responses. Gal-3 has some therapeutic potential in several diseases, including chronic inflammatory disorders, cancer and autoimmune diseases. Gal-3 exerts a broad spectrum of functions which differs according to its intra-or extracellular localization. Recombinant gal-3 strategy has been used to identify potential mode of action of gal-3; however, exogenous gal-3 may not reproduce the functions of the endogenous gal-3. Notably, gal-3 induces monocyte-macrophage differentiation, interferes with dendritic cell fate decision, regulates apoptosis on T lymphocytes and inhibits B-lymphocyte differentiation into immunoglobulin secreting plasma cells. Considering the influence of these cell populations in the pathogenesis of several autoimmune diseases, gal-3 seems to play a role in development of autoimmunity. Gal-3 has been suggested as a potential therapeutic agent in patients affected with some autoimmune disorders. However, the precise role of gal-3 in driving the inflammatory process in autoimmune or immune-mediated disorders remains elusive. Here, we reviewed the involvement of gal-3 in cellular and tissue events during autoimmune and immune-mediated inflammatory diseases.

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Galectin-3 in autoimmunity and autoimmune diseases

Oliveira

Gatto

Bassi

et al. 2015

Exp Biol Med (Maywood)

Self Cite

142

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“…Ze względu na zwiększoną częstość występowania u rasy czarnej podejrzewa się również udział czynników genetycznych [1,2,3].…”

Section: Wstępunclassified

Wpływ wybranych cytokin na uszkodzenie narządów w toczniu rumieniowatym układowym

Kapłon

Brzosko

2018

Pomeranian J Life Sci

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Systemic lupus erythematosus (SLE) is a rheumatic disease with unclear pathogenesis. In the course of this disease a dysfunction of the immune system occurs, which involves the production of autoantibodies and the deposition of immune complexes, which contributes to the damage of various organs. The most commonly involved organs include: kidneys, skin, joints, the eye, respiratory system, and the cardiovascular and nervous systems, both central and peripheral. In recent years there have been reports regarding the role of cytokines in the pathogenesis of various organs' involvement. However, until now it has not been entirely clear which cytokines are responsible for either the stimulation or inhibition of the inflammatory response, which could be helpful in establishing a relationship with the clinical picture. In this article reports are summarized regarding Interleukins 4, 7, 10, 18 (IL-4, IL-7, IL-10, IL-18) and their relationship with organ involvement in SLE. Interleukin 4 is indicated as a protective cytokine by its role in preventing the development of an autoimmune response. In the case of IL-7, it has a role in increasing the proliferation of autoreactive T-cell clones and the development of the disease. The IL-10, despite its protective effect, is found in patients with SLE at significantly higher concentrations than in the general population and correlates with the SLEDAI disease activity level scale. Interleukin 18 has a pro-inflammatory effect, contributing to damage to tissues and organs. In the serum of patients with SLE significantly higher levels of IL-18 were found than in the control group; there was also a statistically significant positive correlation between serum IL-18 levels and SLEDAI disease activity level scale and anti-dsDNA antibody titers. Increasing levels of serum IL-18 in SLE patients is associated with an increased risk of cardiovascular disease. In addition, IL-18 has an important role in the involvement of the kidneys and skin in SLE patients. Keywords: systemic lupus erythematosus; organ involvement; cytokines. ABSTRAKTToczeń rumieniowaty układowy (TRU) jest chorobą reumatyczną o nie w pełni poznanej patogenezie. W przebiegu tej choroby występuje dysfunkcja układu immunologicznego polegająca na wytwarzaniu autoprzeciwciał i odkładaniu się kompleksów immunologicznych, które przyczyniają się do uszkodzeń różnych narządów. Najczęściej zajęte narządy to: nerki, skóra, układ ruchu, narząd wzroku, układ oddechowy, układ sercowo--naczyniowy oraz nerwowy, zarówno ośrodkowy, jak i obwodowy. W ostatnich latach pojawiły się doniesienia dotyczące roli cytokin w patogenezie zajęcia różnych narządów. Jednakże do tej pory nie jest w pełni jasne, które cytokiny są odpowiedzialne za nasilenie, a które za zmniejszenie odpowiedzi zapalnej, co mogłoby pomóc w ustaleniu związku z obrazem klinicznym. W artykule zestawione zostały doniesienia dotyczące Interleukin (IL) 4, 7, 10, 18 oraz ich związku z zajęciem narządowym w przebiegu TRU. W przypadku IL-4 wskazuje się na ochronną rolę tej cyt...

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“…SLE pathogenesis includes aberrant autoantibody production, B-and T-cell abnormalities, irregular lymphocyte apoptosis, and dysregulated cytokine production [1][2][3]. Although the etiology of SLE is still not completely understood, both environmental and genetic factors have been suggested to contribute to the development of SLE.…”

Section: Introductionmentioning

confidence: 99%

Association of P2X7R Functional Expression and Gene Polymorphisms with Systemic Lupus Erythematosus

Jin¹,

Tang²

2015

J Clin Med Genomics

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Objective: To investigate P2X purinoceptor 7 (P2X7R) expression changes on peripheral blood mononuclear cell (PBMC) surfaces of systemic lupus erythematosus (SLE) patients as well as their association with serum cytokine levels and patients' clinical features. In addition, the effects of different P2X7R single nucleotide polymorphisms (SNPs) on P2X7R expression and cytokine production were investigated.Method: Twenty-nine new-onset SLE patients and twenty-eight healthy controls were enrolled, while P2X7R expression levels of lymphocytes, CD4 + cells and CD19 + cells were analyzed by flow cytometry. Serum IL-1β, IL-6 and TNF-α levels were analyzed by ELISA and three P2X7R SNPs (1068G>A, 1096C>G and 1513A>C) were PCR genotyped in 14 SLE patients and 14 healthy controls.Results: P2X7R surface expression levels of lymphocytes, CD4+ and CD19 + cells from new-onset SLE patients were significantly higher than that of controls and significantly elevated on lymphocytes from patients with concurrent arthritis or leukopenia as well as on CD19 + cells of NP-SLE patients. Moreover, P2X7R expression levels on lymphocytes and CD19 + cells of SLE patients were positively correlated with serum TNF-α/IL-6 and TNF-α level, respectively. SLE patients with the P2X7R 1068GG genotype had significantly higher expression level ratios of TNF-α, IL-6 and IL-1β to P2X7R on lymphocytes compared to patients harboring the 1068GA genotype. Conclusion: P2X7R, as an important cell surface regulator of several key cytokines, is involved in the pathogenesis of SLE and also associated with organ injuries like arthritis, leukopenia and neuropsychiatric damage. P2X7R 1068GG maybe a SLE susceptibility genotype since it enhances cytokine secretion in SLE patients.

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Emerging and critical issues in the pathogenesis of lupus

Cited by 116 publications

References 160 publications

Galectin-3 in autoimmunity and autoimmune diseases

Galectin-3 in autoimmunity and autoimmune diseases

Wpływ wybranych cytokin na uszkodzenie narządów w toczniu rumieniowatym układowym

Association of P2X7R Functional Expression and Gene Polymorphisms with Systemic Lupus Erythematosus

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