Guo et al.: Laparoscopic Cholecystectomy Efficacy in the Treatment of Acute CholecystitisTo evaluate the efficacy of laparoscopic cholecystectomy in the treatment of senile acute cholecystitis. A total of 96 elderly patients with acute cholecystitis admitted to our hospital from January 2014 to January 2019 were selected and all the patients were divided into groups according to their treatment timing. Patients within 3 d from the onset of the disease to the operation time were selected as Group A. Patients with an onset time of 3 d to 3 w of surgery were treated as Group B, while patients with an onset time of more than 3 w of surgery were treated as Group C. The operative time, intraoperative blood loss, postoperative intestinal function recovery time and hospital stay time were compared among the groups. Postoperative complications such as bleeding, pulmonary infection, abdominal infection, bile leakage and intestinal fistula, deep vein thrombosis and myocardial infarction were compared among all groups. Compared with Group A, there were no significant differences in intraoperative blood loss, operative time, postoperative bowel function recovery and length of hospital stay in Group B (p>0.05). Compared with group A and B, patients in Group C had higher operative time, intraoperative blood loss, postoperative intestinal function recovery and hospital stay (p<0.05). After surgery, there were no significant differences in bleeding, pulmonary infection, abdominal infection, bile leakage and intestinal fistula, deep vein thrombosis, or complications of myocardial infarction among the groups (p>0.05). Early laparoscopic cholecystectomy can reduce intraoperative blood loss, operation time, hospital stay and recovery time of intestinal function in elderly patients with acute cholecystitis.