Emergent therapy with therapeutic plasma exchange in acute recurrent pancreatitis due to severe hypertriglyceridemia

Kadıköylü, Gürhan; Yukselen, Vahit; Yavaşoğlu, İrfan; Çoşkun, Adil; Karaoglu, A. Onder

doi:10.1016/j.transci.2010.09.009

Cited by 26 publications

(34 citation statements)

References 19 publications

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“…Table 1 summarizes main demographic data, comorbidities, type of replacement, serum TG before plasma exchange is done, the percentage of reduction and the in-hospital mortality for those papers published including more than five patients [63][64][65][66][67][68][69][70][71]. One single session of plasma exchange is able to reduce serum TG from 49 to 80%, although few patients need two or more sessions to reach a TG level below 1000 mg/dL.…”

Section: Plasmapheresismentioning

confidence: 99%

“…Regular Table 1 Main data from studies of HTG-AP treated with plasmapheresis, reporting more than 5 patients. plasmapheresis can also be used in severe HLP type I or type V to avoid recurrent HTG-AP [69,71,80,81]. For patients with HLP type IV or V, it is compulsory to control all environmental factors that are associated with poor TG control, such as alcohol consumption, uncontrolled diabetes mellitus, estrogens, retinoid and if possible antiretroviral agents.…”

Section: Long-term Managementmentioning

confidence: 99%

See 1 more Smart Citation

Current knowledge of hypertriglyceridemic pancreatitis

Valdivielso¹,

Ramírez-Bueno²,

Ewald³

2014

European Journal of Internal Medicine

354

311

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Section: Plasmapheresismentioning

confidence: 99%

Section: Long-term Managementmentioning

confidence: 99%

Current knowledge of hypertriglyceridemic pancreatitis

Valdivielso¹,

Ramírez-Bueno²,

Ewald³

2014

European Journal of Internal Medicine

354

311

View full text Add to dashboard Cite

“…In patients with severe hypertriglyceridemia (triglyceride level > 1000 mg/dl), reducing triglyceride levels may be necessary. Therefore therapeutic plasma exchange (TPE) has been used as emergent therapy to reduce the risk of pancreatitis [19].…”

Section: Discussionmentioning

confidence: 99%

The clinical course of chronic pancreatitis associated with lipid disturbances in children

Oracz¹,

Kierkuś²,

Socha³

et al. 2012

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K Ke ey y w wo or rd ds s: : chronic pancreatitis, lipid disturbances, hypertriglyceridemia, children. S Sł ło ow wa a k kl lu uc cz zo ow we e: : przewlekłe zapalenie trzustki, zaburzenia lipidowe, hipertriglicerydemia, dzieci.A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Grzegorz Oracz MD, PhD Medical records of these patients were reviewed for clinical presentation and diagnostic findings. R Re es su ul lt ts s: : Lipid disturbances were found in 25 patients (13.8%). Hypertriglyceridemia was detected in 15 patients, hypercholesterolemia in 14 patients. In 10 patients with CP and lipid disturbances other factors causing CP were present (gene mutations in 6 patients and anatomic anomalies in 6 patients). There was no statistically significant difference in the clinical course between the hyperlipidemic (HA group) and non-hyperlipidemic group (NHA group). C Co on nc cl lu us si io on ns s: : Chronic pancreatitis associated with lipid disturbances is common in children and has a similar clinical course as chronic pancreatitis without lipid disturbances. We should be aware of coexistence of hyperlipidemia and other factors causing pancreatitis, such as gene mutations.

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“…In the acute phase, chylomicrons can be directly removed from the circulation by plasmapheresis [31]. Furthermore, AP is a hyper coagulable state associated with an increased risk of thrombotic complications [32].…”

Section: Hypertriglyceridemia-induced Acute Pancreatitis: Clinical Comentioning

confidence: 99%