Background
Body roundness index (BRI) is an obesity-related anthropometric index that combines waist circumference (WC) and height to better reflect body fat. This study aims to prospectively explore the relationship between BRI and the risk of hypertension based on a population cohort of the Chinese Western region.
Methods
The study data came from a natural population cohort of Guizhou province established in 2010, and a total of 9,280 people in 48 townships in 12 districts (counties) were surveyed at baseline using multistage stratified randomized whole cluster sampling. Follow-up surveys were completed from 2016 to 2020, and after excluding deaths, lost visits, baseline hypertension, unclear follow-up hypertension diagnosis, and missing relevant variables, a final 5,230 people entered the analysis. Cox proportional risk models were used to analyze the association between BRI and the development of hypertension and to calculate hazard ratios (HRs) and 95% CIs. Analyzing the relationship between BRI and time to onset of hypertension using the time failure acceleration model.
Results
The total person-years (PYs) of follow-up were 36,950.24 years, with a median follow-up time of 6.64 years. During the follow-up period 1157 study subjects developed new hypertension with an incidence density of 31.31/1000 PYs. After adjusting for confounding variables, BRI increased the risk of hypertension by 17% per unit increase (HR = 1.17,95% CI: 1.108–1.235, P trend < 0.001). Compared with the population in the first quartile (Q1) of BRI, the risk of hypertension in the population in the third quartile (Q3) and fourth quartile (Q4) is 1.309 (95% CI: 1.1-1.558) and 1.534 (95% CI: 1.282–1.837), respectively. For each unit increase in BRI, the onset of hypertension is advanced by 0.255 years (95% CI: -0.348-0.162).
Conclusion
There is a significant correlation between elevated body mass index (BRI) and an increased propensity for hypertension, BRI could serve as a valuable instrument for weight management among individuals already diagnosed with hypertension.