Emergency management of diabetic ketoacidosis in adults

Expedited Discharge of Patients with Diabetic Ketoacidosis in an Emergency Department Short Stay Unit

“…Noncompliance by patients of their insulin regimen was documented in sixty one out of seventy six patients on insulin. This is in line with many studies done on this subject, accounting for nearly two thirds of cases (except DKA as first presentation of Diabetes Mellitus) [2] [5] [6].…”

“…We achieved a rapid reversal and improvement in abnormal pH and ketosis by timely diagnosis and early initiation of fluid resuscitation and intravenous insulin therapy [1] [2] [4] [6]. We usually did not change the fluid back to saline once it was changed to dextrose containing fluid unless the blood sugar was not controlled with incremental doses of intravenous insulin.…”

“…DKA adds to morbidity and mortality amongst patients with diabetes. Mortality rates in DKA, quoted at <5%, increase substantially with increasing age and concomitant critical illnesses [1]- [6].…”

Toward Carbon Monoxide–Based Therapeutics: Critical Drug Delivery and Developability Issues

“…For example, the normal glucose level is 5.8 mM and yet 14 mM of glucose can be life threatening. 26 With insulin, there is no consistent level that is considered “normal” because of the daily fluctuation. However, it is commonly believed that staying below 10 μIU/mL is healthy, 27 and yet 50 μIU/mL would completely suppress hepatic glucose output, which would be life-threatening without therapeutic intervention by administering glucose to the patient.…”

Pattern of Precipitating Causes of Diabetic Ketoacidosis in A Tertiary Care Hospital of Bangladesh

“…Most of the type 1 diabetic patients first present with DKA 1 , but DKA commonly complicate previously diagnosed diabetic patients of any type,especially if they get Outcome depends on rapidity of diagnosis andinitiation of appropriate treatment, severity of the disease, age of the patient, identification of precipitating factor and its treatment, presence of co-morbidities and organ dysfunction. [6][7][8] This study was designed to evaluate the precipitating causes of DKA among adult patients in a tertiary carehospital of Bangladesh. 9 ; mild DKA: an arterial pH of 7.25-7.30, moderate DKA: arterial pH 7.0-7.24 and severe DKA: arterial pH <7.0.…”