Emergency Drug Analysis

Sine, H E; McKenna, M. J.; Law, Marcus; Murray, Martin

doi:10.1093/chromsci/10.5.297

Cited by 8 publications

(2 citation statements)

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“…Usually 10-15 measurements were done. Drug levels were measured using the following methods: phénobarbital [10], pentobarbital [11], glutethimide [12], salicylate [13], methsuximide and N-desmethylmethsuximide [14], elhchlorvynol [15], metaqualone [16], propoxy phene [17], chlordane [18], No drug measurements were done for patients D.J. …”

Section: Patient Studiesmentioning

confidence: 99%

Fixed-Bed Uncoated Charcoal Hemoperfusion in the Treatment of Intoxications: Animal and Patient Studies

Torrenté¹,

Rumack²,

Blair³

et al. 1979

Nephron

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We examined the efficacy of a new, fixed-bed, uncoated charcoal device in experimentally intoxicated dogs and in drug-intoxicated as well as chemically poisoned patients. In the animal studies, 4 h of hemoperfusion resulted in a significant decrease in the blood level of phenobarbital, salicylate, pentobarbital and glutethimide. The drug clearances varied between 97 ± 10 and 129 ± 6 ml/min. However, the total amount of drug removed was higher for phenobarbital and salicylate which have a small apparent volume of distribution (AV_D) than for pentobarbital and glutethimide which have an AV_D greater than total body water. We next treated 14 patients suffering from a wide variety of intoxications. Patients intoxicated with phenobarbital, methsuximide, chlordane and Amanita muscaria all showed a significant improvement in their clinical status. Patients intoxicated with ethchlorvynol, glutethimide, methaqualone, podophylhn and fluoroacetamide did not improve. Charcoal hemoperfusion may be useful in patients poisoned with drugs characterized by an AV_D smaller than total body water. No major complications were encountered during the hemoperfusions.

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Section: Patient Studiesmentioning

confidence: 99%

Fixed-Bed Uncoated Charcoal Hemoperfusion in the Treatment of Intoxications: Animal and Patient Studies

Torrenté¹,

Rumack²,

Blair³

et al. 1979

Nephron

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“…Finally, a few interesting and noval applications include the GC determination of penicillins (389), the identification and quantitative determination of microgram amounts of "street heroin" (212, 625), hallucinogens (779), and the drugs in opium extract (64), a GC/MS reference data system with MS base peak index for 133 drugs of abuse (259), and a rapid £<3 hr) analytical method for emergency drug analyses (796). The analysis of the C15-Cse n-alkanes in air particulate matter (377), the identification of spilled residual fuel oils (464), and the characterization of organic components in municipal water supplies (490) are representative of the many applications of GC to pollution studies.…”

Section: Detectorsmentioning

confidence: 99%

Gas chromatography

Juvet¹,

Cram²

1974

Anal. Chem.

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This review surveys developments in the field of gas chromatography since publication of the last review in this series (178) and covers the years 1972-73. Gas chromatography continues to be one of the most active areas in analytical chemistry. In the 1973 Directory of Membership of the ACS Division of Analytical Chemistry (356), those listing their research specialty as "gas chromatography" were second in numbers only to those listing the drugs compiled by the editorial staff (423) and articles on applications of GC in alcohol analysis (417), hallucinogenic drugs ( 818), the analysis of narcotic analgesics and amphetamines (622), barbiturates (446), and phenothiazine drugs (158).

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