Emergency Department Visits Caused by Adverse Drug Events

Queneau, Patrice; Bannwarth, B; Carpentier, F.; Guliana, J. M.; Bouget, J.; Trombert, Béatrice; Leverve, Xavier; Lapostolle, Frédéric; Borron, Stephen W.; Adnet, Frédéric

doi:10.2165/00002018-200730010-00008

Cited by 85 publications

(60 citation statements)

References 28 publications

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“…In our study, antihypertensives, antidiabetics, anti-asthmatics, and drugs used in CNS disorders were most frequently implicated, similar to drug classes reported by other studies [11,13,36,38]. Some of these drugs have a narrow therapeutic index, which has been associated with a higher risk of drug-related hospitalization [39].…”

Section: Discussionsupporting

confidence: 85%

“…If the patient had other symptoms related to drug use, and the chief presenting complaint was not related to these symptoms, the ED visit was considered to be not drug-related [4]. Determination of whether the visit to the ED was related to a drug or not also took into consideration the following factors [13]: (1) a known drug action, as described in the drug monographs and/or literature; (2) the temporal relationship between the event and the time of drug use; and (3) the nature of the current underlying disease(s).…”

Section: Definitions and Case Identificationmentioning

confidence: 99%

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Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

2017

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Introduction Adverse drug events (ADEs) are a significant health problem globally, with the emergency department (ED) being an important environment for the detection of ADEs. Data regarding drug-related visits to the ED in Malaysia are currently limited.Objectives The aim of this study was to determine factors associated with prescription drug-related ED visits at a teaching hospital. Methods A case-control study was conducted on patients who visited the ED of Hospital Universiti Sains Malaysia over a 7-week period between December 2014 and January 2015. A visit to the ED was considered drug-related if the chief presenting complaint was related to prescription drug use. Data were collected by interviewing patients, and also from the patient's medical record. Multiple logistic regression was applied to determine the risk factors. Results Overall, 144 physician-identified patients with drug-related ED visits were considered as cases and 288 patients with non-drug-related complaints were selected as controls. Independent risk factors identified for drug-related ED visits were female sex (adjusted odds ratio [OR] 1.7, 95% confidence interval [CI] 1.03-2.71), currently taking regular medication (OR 3.4, 95% CI 1.87-6.05), concurrent comorbidity (OR 2.3, 95% CI 1.28-4.10), a history of drug allergy (OR 5.36, 95% CI 2.30-12.48), and recent hospital admission (OR 2.85, 95% CI 1.23-4.10). Independent risk factors were also associated with the following health problems: diabetes mellitus (OR 6.83, 95% CI 3.30-14.12), central nervous system disorders (OR 9.42, 95% CI 3.08-14.12), and cardiovascular disorders (OR 2.5, 95% CI 1.25-4.79).Conclusions The determinants of a drug-related ED visit at a teaching hospital are multifactorial. Interventions to prevent future occurrences should focus on those patients at risk. Key PointsFemale sex, receiving regular medication, having a history of drug allergy, and recent hospital admission are risk factors for prescription drug-related emergency department (ED) visits.Patients with health problems such as diabetes, central nervous system disorders, and cardiovascular disorders also have a higher risk of ED visits related to drug use.The most common drug classes involved with drugrelated ED visits were antidiabetic agents, antihypertensives, antibiotics, anti-asthmatics, and diuretics.

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Section: Discussionsupporting

confidence: 85%

Section: Definitions and Case Identificationmentioning

confidence: 99%

Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

2017

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“…Most of these interactions require regular monitoring and many can be circumvented by using safer alternatives. As mentioned before, adverse drug events account for about 6 % of hospital admissions [4,5] with very high costs associated Int J Clin Pharm [6]. The existence of a more cost-effective equivalent is also a common DRP (19.11 %).…”

Section: Discussionmentioning

confidence: 99%

“…Morbidity and mortality associated with medication is widely described in the literature. Over 20 % of visits to emergency departments are related to medicines use [2][3][4]. In the U.S., drug related problems (DRPs) represent the 4th-6th leading cause of death and adverse reactions are responsible for 3-6 % of hospitalizations (700,000 patients/year) [5], representing an estimated cost of 130 billion dollars [6].…”

Section: Introductionmentioning

confidence: 99%

Drug-related problems in institutionalized, polymedicated elderly patients: opportunities for pharmacist intervention

Silva

Ramalho²,

Luz³

et al. 2015

Int J Clin Pharm

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“…However, such a procedure exposes the patient to possible side-effects. In fact, around 21% of all outpatients suffer some kind of adverse reaction to drugs prescribed by their physician (Queneau et al, 2007). By investigating drug metabolism related to individual genetic polymorphism, pharmacogenetics has a significant impact on the clinical setting so that forensic implications may arise throughout the public health sector.…”

Section: Personalized Therapy: Ethical and Legal Issuesmentioning

confidence: 99%

Forensic Pharmacogenetics

Pelotti¹,

Bini²

2011

Forensic Medicine - From Old Problems to New Challenges

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Emergency Department Visits Caused by Adverse Drug Events

Abstract: ADEs leading to emergency department visits are frequent, and many are preventable, confirming that there is a need to develop prevention strategies.

Cited by 85 publications

References 28 publications

Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

Drug-related problems in institutionalized, polymedicated elderly patients: opportunities for pharmacist intervention

Forensic Pharmacogenetics

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