Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate

Abstract

Background/aim: Bleeding in patients undergoing coronary artery bypass grafting (CABG) while using dual antiplatelet therapy (DAPT) is a cause of significant morbidity and mortality. The aim of this study is to examine the perioperative hemostatic effects of tranexamic acid (TnX-A) and desmopressin acetate (Des) in these patients. Materials and methods:This clinical study was planned in a prospective and randomized manner. Fifty-four patients were enrolled and classified into 4 different groups. They were compared in terms of various bleeding and transfusion parameters.Results: No significant differences were observed between the groups in pre/intraoperative data apart from closure times. Plasmin/α-2 antiplasmin complex values in the TnX-A and control groups were significantly higher than those in the Des and TnX-A+Des groups at the end of postoperative drug infusion. Mean duration of closure times, first 3-h and total postoperative amounts of drainage, administered volumes of erythrocyte suspension/fresh frozen plasma, cost of blood products, length of intubation, length of stay in the intensive care unit, and time to discharge were also significantly higher in the Des and control groups. Conclusion:Des had no significant effect on bleeding control and even delayed the hemostatic efficacy of TnX-A. Use of TnX-A infusion alone in these patient groups had a positive effect on hemostasis-related data.

The diagnostic value of combined detection of genetic markers and serum protein markers on breast cancer

“…In this research, the expression levels of TPS, CA153 and CEA in breast cancer group were significantly higher than those of benign breast tumor group and control group. The sensitivity, specificity, and the area under the curve all indicate that separate detection has certain value too, however considering comprehensively, combined detection is better than separated detection, which is consistent with the research conducted by Zheng and Luo, 2005, Yildirim et al, 2017, Khan et al, 2018, Golezar et al, 2017, Altun et al, 2017, Gao et al, 2017.…”

Evaluating the Effectiveness of Snyder's Theory-Based Group Hope Therapy to Improve Self-Efficacy of University Students in Finance

“…The concept of self-efficacy has been adapted from the social recognition theory of Albert Bandura, a famous psychologist, who refers to the role of individual beliefs and judgments in ability to perform his duties (Altun et al, 2017;Hajare and More, 2017;Hamad et al, 2018;Kevrekidis et al, 2018;Khan et al, 2018;Taheri et al, 2017). Many of human behaviors are self-excited and controlled by effective mechanisms, which belief in personal self-efficacy is more important and more comprehensive than the rest (Bandura, 1997).…”

Hemostatic effects of tranexamic acid in cardiac surgical patients with antiplatelet therapy: a systematic review and meta-analysis

“…A total of 392 trials were excluded due to duplication and review of titles and abstracts. Finally, 12 (Pleym et al 2003 ; Ahn et al 2012 ; Shi et al 2013a , 2013b , 2013c ; Altun et al 2017 ; Banihashem et al 2019 ; Khadanga et al 2020 ; Landymore et al 1997 ; Guo et al 2007 ; Aelbrouck et al 2016 ; Myles et al 2017 ) eligible trials that satisfied the inclusion criteria were included in this meta-analysis. Descriptive analyses of these articles were presented in Table 1 .…”

“…Descriptive analyses of these articles were presented in Table 1 . Of the 12 eligible trials, 2 (Shi et al 2013b ; Guo et al 2007 ) were written in Chinese, the other 10 (Pleym et al 2003 ; Ahn et al 2012 ; Shi et al 2013a , 2013c ; Altun et al 2017 ; Banihashem et al 2019 ; Khadanga et al 2020 ; Landymore et al 1997 ; Aelbrouck et al 2016 ; Myles et al 2017 ) were in English (1 (Ahn et al 2012 ) from Korea, 2 (Shi et al 2013a , 2013c ) from China, 1 (Altun et al 2017 ) from Turkey, 1 (Banihashem et al 2019 ) from Iran, 1 (Khadanga et al 2020 ) from India, 1 (Landymore et al 1997 ) from Canada, 1 (Pleym et al 2003 ) from Norway, 1 (Aelbrouck et al 2016 ) performed in Belgium and USA, 1 (Myles et al 2017 ) performed in Australia, Canada, Italy, the Netherlands, New Zealand, China (Hong Kong), and UK). Seven trials (Pleym et al 2003 ; Shi et al 2013a , 2013b , 2013c ; Altun et al 2017 ; Banihashem et al 2019 ; Landymore et al 1997 ) included participants undergoing on-pump CABG, three trials (Ahn et al 2012 ; Khadanga et al 2020 ; Guo et al 2007 ) included off-pump CABG patients, and two trials (Aelbrouck et al 2016 ; Myles et al 2017 ) included mixed cardiac surgical patients.…”