Emergency contraception potential of leptin signaling inhibition in a mouse model

González, Ricardo R.; Cherfils, Salandre; Ngugi, Daina; Cipriani, Penelope; Olatinwo, Moshood; Rueda, Bo R.

doi:10.1016/j.fertnstert.2007.07.182

Cited by 1 publication

(2 citation statements)

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“…Pharmacokinetic studies with radiolabeled antagonist revealed localization mainly in the ovaries, uterus, and mammary glands, and no significant amounts in the central nervous system (164). In addition, there was no effect on energy metabolism (165). These results indicate that reproductive organs can be affected by the inhibitory peptide without any traverse of the blood-brain barrier or interference with energy metabolism.…”

Section: New Leads For Contraceptivesmentioning

confidence: 69%

“…The antagonist, with or without PEGylation, was absorbed from a vaginal gel formulation and localized to the leptin receptors in the mouse uterus (164). Vaginal treatment with the PEGylated antagonist on days 1-6 postcoitum in mice completely prevented implantation (165). Pharmacokinetic studies with radiolabeled antagonist revealed localization mainly in the ovaries, uterus, and mammary glands, and no significant amounts in the central nervous system (164).…”

Section: New Leads For Contraceptivesmentioning

confidence: 99%

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As the world grows: contraception in the 21st century

Aitken¹,

Baker²,

Doncel³

et al. 2008

J. Clin. Invest.

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Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Most available methods use hormonal steroids or are variations of barrier methods. Reports from several fora over the last 12 years have emphasized the number of unwanted pregnancies and resultant abortions, which indicate an unmet need for safe, acceptable, and inexpensive contraceptive methods. This unmet need can be assuaged, in part, by development of new nonhormonal contraceptive methods. This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development.

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Section: New Leads For Contraceptivesmentioning

confidence: 69%

Section: New Leads For Contraceptivesmentioning

confidence: 99%