Recognized as the basis for maintaining the functionality of the community in disaster conditions, the protection of critical infrastructure is one of the most important measures to improve the resilience of society. Starting from the fact that society can be affected by various natural and anthropogenic disasters, the subject of this chapter refers to a comprehensive analysis of the security aspects of critical infrastructure protection in anthropogenic (man-made) disasters. On the other hand, the social goal of the research is to determine the level of public awareness of the importance of protecting critical infrastructure from these disasters. By applying the quantitative research tradition, quantitative research was realized in the area of the city of Belgrade, in which 200 respondents were interviewed by the method of random sampling. The obtained research results unequivocally indicate that preventive action in this area should be mainly focused on the adoption of strategies based on which plans are made to prevent the occurrence of these disasters, as well as operational procedures for the protection of critical infrastructure.