“…Under normal operating conditions, spacecraft and lifesupport systems are designed to protect occupants from lethal events associated with exposure to the atmosphere and the lack thereof. 9 Travel away from the Earth's surface results in a progressive loss of atmospheric pressure, an increased potential for exposure to ionizing ra- diation, and a temperature cycling as crews travel through the troposphere, stratosphere, mesosphere, thermosphere, and exosphere. 10 Spacecraft have carried crews to a number of operational distances from the Earth's surface, thereby exposing crews to different potential stressors.…”