Emergencia del genotipo Cosmopolitan del virus dengue serotipo 2 (DENV2) en Madre de Dios, Perú, 2019

Abstract

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Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil

“…Cosmopolitan lineages continue to expand geographically, and recent introductions have been reported in Asia and Africa (7,8). In South America, the cosmopolitan genotype was detected in Peru in 2019 and spread mainly in Madre de Dios Province, where 4,893 total dengue cases were reported during that year (9). However, much is still unknown about its genomic diversity, evolution, and transmission dynamics in the region.…”

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

“…In areas of southern Asia, including Nepal 2017, Sri Lanka 2017–2018, Bangladesh 2017–2018, the Maldives 2017–2019, India 2021, and Pakistan 2022 [ 35 , 36 , 37 ], the cosmopolitan lineage C virus emerged, and this is where the lineage B (Indian) virus had previously circulated. Furthermore, the cosmopolitan lineage C virus spread for the first time to South America, with local transmission reported in Peru in 2019 [ 38 ] and Brazil in 2022 [ 39 ], both of which were mostly related to the Bangladesh 2017 virus [ 37 ]. It is possible that the cosmopolitan lineage C virus successfully adapted to humans, particularly in transmission fitness, resulting in its spread to a wider area and an increase in cases of infection.…”

Dengue-2 Cosmopolitan genotype detection and emergence in South America

“…Cosmopolitan lineages continue to expand geographically, with recent new introductions reported globally, such as in Asia and Africa (7,8). In the Americas, Cosmopolitan genotype reached Peru at the beginning of 2019, spreading mainly along the year in Madre de Dios province, were 4,893 total dengue cases were reported in 2019 (9). However, after its first detection, much is still unknown about its genomic diversity, evolution and transmission dynamics in the region.…”

“…To put the newly DENV-2 Cosmopolitan genotype sequence in a global context, we constructed phylogenetic trees to explore the relationship of the sequenced genome to those of other isolates of this genotype. We retrieved 1,087 DENV-2 genome sequences from this genotype with associated lineage date and country of collection from GenBank, including the first 2 South American strains isolated in Peru in 2019 (9). Sequences were aligned using MAFFT (12) and edited using AliView (13).…”