“…Multidrug resistance in V. cholerae O1 isolates has so far been linked to plasmids, and the presence of self-transmissible multidrug-resistant plasmids from 100 to 200 kb has been reported in V. cholerae O1 isolates from Asia, Africa, and Ecuador (10,14,19,33,40,41,43) more recently, in isolates from Albania, Italy, and Brazil (11,15). However, plasmids such those harbored by isolates M1516 and M3030, which encode resistance to gentamicin, kanamycin, amikacin, streptomycin, trimethoprim-sulfamethoxazole, tetracycline, and chloramphenicol and, in the case of M1516, to erythromycin, in addition to -lactam antibiotic resistance, have not previously been reported.…”