Emergence of β-Lactam Multiresistant Variants of Gram-negative Bacilli in the Presence of Cefotaxime

Pl, Svarva; Rv, Lyng; Ja, Maeland

doi:10.3109/13813458509058779

Cited by 5 publications

(4 citation statements)

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“…Multiply drug resistant strains of gram negative enteric organisms, e.g. Klebsiella, are also known to flourish in the presence of third generation cephalosporins (22,23).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis in Pakistan: Presentation and Pathogens

et al. 1991

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The case records of all neonates admitted to the neonatal unit at Aga Khan University Hospital (Karachi) in a 30 month period (Nov. 86-April 89) were analysed. Of 60 neonates with confirmed sepsis, 33 (55%) had non-nosocomial infection (NNC) whereas 27 (45%) had nosocomial sepsis (NC). The most common organisms causing early-onset NNC sepsis were Klebsiella species (53%) and Escherichia coli (10%), whereas the organisms causing late-onset NNC sepsis included Salmonella parathypi (21%), Group A Streptococcus (21%), Escherichia coli (14%) and Pseudomonas species (14%). Klebsiella was the most common organism causing NC sepsis, others being Staphylococcus aureus (15%) and Serratia species (15%). The mortality in NC sepsis, early-onset and late onset NNC sepsis was 44%, 26% and 43%, respectively. Risk factors associated with NNC sepsis included low birthweight, prematurity and prolonged and complicated deliveries. There was a high incidence of drug resistance to ampicillin and gentamicin among gram-negative organisms causing sepsis (mean 67%).

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“…Multiply drug resistant strains of gram negative enteric organisms, e.g. Klebsiella, are also known to flourish in the presence of third generation cephalosporins (22,23).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis in Pakistan: Presentation and Pathogens

et al. 1991

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“…To this end, we have shown that the mice expressing the KC transgene in the lungs display enhanced resistance to intrapulmonary challenge with Klebsiella pneumoniae (47). Given the emergence of highly resistant bacterial pathogens and the increasing population of immunocompromised hosts (5,11,43), the treatment of bacterial infection has been and will continue to be quite difficult. Therefore, immunomodulation of host responses, especially if delivered in a site-directed fashion, may prove to be an attractive adjuvant to conventional antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in MurinePseudomonas aeruginosaPneumonia

et al. 2000

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“…Despite the development of new broad-spectrum antibiotics, bacterial pneumonia continues to be a major cause of morbidity and mortality in this country (4,20). The emergence of multidrugresistant microbes in the immunocompromised host has made the treatment of these infections increasingly difficult (5,27), highlighting the importance of immune host defense in determining the eventual outcome of severe bacterial infection.…”

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confidence: 99%

Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia

et al. 1996

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Tumor necrosis factor (TNF) is a proinflammatory cytokine which has recently been shown to have beneficial effects in the setting of acquired host immunity. However, the role of TNF in innate immune responses, as in the setting of bacterial pneumonia, has been incompletely characterized. To determine the role of TNF in gram-negative bacterial pneumonia, CBA/J mice were challenged with 10 2 CFU of Klebsiella pneumoniae intratracheally, resulting in the time-dependent expression of TNF MRNA and protein within the lung. Passive immunization of animals with a soluble TNF receptor-immunoglobulin (Ig) construct (sTNFR:Fc) intraperitoneally 2 h prior to K. pneumoniae inoculation resulted in a significant reduction in bronchoalveolar lavage neutrophils, but not macrophages, at 48 h, as compared with animals receiving control IgG1. Furthermore, treatment with sTNFR:Fc resulted in 19.6-and 13.5-fold increases in K. pneumoniae CFU in lung homogenates and plasma, respectively, as compared with animals receiving control IgG1. Finally, treatment of Klebsiellainfected mice with sTNFR:Fc markedly decreased both short-and long-term survival of these animals. In conclusion, our studies indicate that endogenous TNF is a critical component of antibacterial host defense in murine Klebsiella pneumonia.

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Emergence of β-Lactam Multiresistant Variants of Gram-negative Bacilli in the Presence of Cefotaxime

Cited by 5 publications

References 0 publications

Neonatal Sepsis in Pakistan: Presentation and Pathogens

Neonatal Sepsis in Pakistan: Presentation and Pathogens

CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in MurinePseudomonas aeruginosaPneumonia

Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia

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