Emergence of virulent pseudorabies virus infection in Northern China

Wu, Ronghan; Bai, Chaoyong; Sun, Jinzhong; Chang, Shengke; Zhang, Xuke

doi:10.4142/jvs.2013.14.3.363

Cited by 119 publications

(121 citation statements)

References 4 publications

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“…This suggested that the PR vaccine was not effective against wild-type PR infection. According to recent studies, the causative agent of the outbreak was a PRV variant that showed enhanced pathogenicity [3,7,8,10]. In the present study, the PRV strain SH2012 was isolated in 2012 from an infected pig farm in Shanghai, China that used the typical vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…The causative agent of the outbreaks was confirmed to be a PRV variant [3,9]. The PRV variant was shown to be both antigenically different from the classical PRVs and more pathogenic in older pigs [3,7,8,10]. Previous studies on immunological protection in sheep have shown that the Bartha-K61 vaccine does not provide complete protection against the emerging PRV variant, but could offer full protection against infection with PRV strain SC (an earlier virulent strain in China) [3,11].…”

Section: Introductionmentioning

confidence: 99%

“…From the 1990s to 2010, the Bartha-K61 vaccine was widely used in Chinese pig herds and PR was effectively controlled [3,4]. However, in October 2011, a severe PRV outbreak occurred in Bartha-K61-vaccinated pig herds on many Chinese farms, resulting in considerable economic losses [5][6][7][8]. The causative agent of the outbreaks was confirmed to be a PRV variant [3,9].…”

Section: Introductionmentioning

confidence: 99%

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Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Ju¹,

Yang²,

Wang³

et al. 2017

Eur J Exp Bio

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For many years, pseudorabies has been efficiently controlled in China by vaccination. However, a sudden outbreak occurred on many pig farms during 2012-2013. In this study, phylogenetic analysis was carried out with the aim of understanding the genetic relatedness between strains in both populations and comparing strains in China with those circulating in other countries. To obtain more pathogenetic relevant data regarding two pseudorabies virus (PRV) isolates (SH2010 and SH2012) in sheep, we evaluated samples of PRV isolated in Shanghai, China between 2010 and 2012. Based on clinical signs, body temperature variation, and the maximum amounts of viral DNA in unvaccinated/infected sheep, the emerging PRV variant strain, SH2012 was observed to be more highly virulent than the traditional PRV SH2010 strain. The data of the present study will aid in a better understanding of the differences in pathogenicity between the traditional PRV SH2010 strain and the emerging PRV variant strain SH2012.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Ju¹,

Yang²,

Wang³

et al. 2017

Eur J Exp Bio

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show abstract

“…17,18 PRV continues to spread worldwide, especially among some countries in South America, Europe, and Asia, while others, including Germany, Sweden, Denmark, and England, have eradicated PR. The United States, France, Poland, and other countries have eradicated PR among domestic pig populations (Lipowski A, Pejsak Z, Antibody prevalence of pseudorabies virus in feral pigs in Poland, In: Proceedings of 17th International Pig Veterinary Society Congress, 2002;2:223).…”

mentioning

confidence: 99%

Outbreak of variant pseudorabies virus in Bartha-K61–vaccinated piglets in central Shandong Province, China

Zhang

et al. 2015

J VET Diagn Invest

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An epidemic that mainly endangered 3–7-day-old piglets struck many farms in Shandong Province, China in 2013 and caused heavy losses. To identify the pathogenesis, the type of lesions, and the causative agent, systemic examinations were performed. Autopsy showed multiple lesions, including necrotic foci of the spleen and liver, punctate hemorrhage of the renal cortex, and interstitial pneumonia. Histological examinations showed typical nonsuppurative encephalitis, necrotic lymphocytes, and reticuloendothelial cells in lymphatic tissues, as well as eosinophilic inclusion bodies in the nuclei of reticuloendothelial cells, necrotic foci in liver cells, and hemorrhagic glomeruli. The average seroprevalence rate of field pseudorabies virus (PRV; Suid herpesvirus 1) of a representative farm tested by enzyme-linked immunosorbent assay was 46%, indicating that the PRV infectious pressure was quite severe especially among gilts, young multiparous sows, boars, and growing–finishing pigs. The glycoprotein E (gE) gene of PRV was detected in 8 of 10 clinical samples, and the virus in the positive samples induced obvious cytopathic effects. An immunoperoxidase monolayer assay showed that PRV antigens were distributed both in the nucleoli and cytoplasm of infected cells. Sequencing and phylogenetic analysis of the gE gene showed that the strain isolated herein, TaiAn SD 2013, was highly similar to previously isolated strains, especially those isolated in northern China in 2013, and was closely related to other isolates from Asia. Evidence confirmed that the variant PRV was the etiologic agent of this epidemic, suggesting that the Bartha-K61 vaccine does not provide complete protection against PRV infection. Further challenge tests are ongoing to investigate the virulence of variant PRV.

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“…Black triangles show cities with seropositive samples. Original image: (Wu et al 2013) direction) makes it a useful live neural tracer and activity reporter (Boldogkoi et al 2009), further extending its research value.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis of Pseudorabies virus reveals selective regulation of different kinetic classes of genes

Póka¹

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Emergence of virulent pseudorabies virus infection in Northern China

Abstract: Our investigation was conducted in order to verify a recent severe epidemic at several swine farms in northern China that indicated a newly emerging disease. Evidence confirmed that the epidemic was caused by a virulent Pseudorabies virus infection in swine herds.

Cited by 119 publications

References 4 publications

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Outbreak of variant pseudorabies virus in Bartha-K61–vaccinated piglets in central Shandong Province, China

Transcriptome analysis of Pseudorabies virus reveals selective regulation of different kinetic classes of genes

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